Larotrectinib Response in NTRK3 Fusion-Driven Diffuse High-Grade Glioma
High-grade glioma (HGG) and glioblastoma are the most common adult malignant brain tumors. The standard treatment consists of surgical resection followed by radiochemotherapy with temozolomide. The prognosis and the therapeutic options of these malignant brain tumors however are limited. Here, we describe a case of a patient with HGG with a previously unknown NTRK3 fusion that showed an extraordinary response to treatment with larotrectinib. This case supports regular testing for NTRK fusion proteins.
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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Larotrectinib Response in NTRK3 Fusion-Driven Diffuse High-Grade Glioma ; volume:107 ; number:7-8 ; year:2022 ; pages:433-438 ; extent:5
Pharmacology ; 107, Heft 7-8 (2022), 433-438 (gesamt 5)
- Creator
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König, David
Hench, Jürgen
Frank, Stephan
Dima, Laura
Bratic Hench, Ivana
Läubli, Heinz
- DOI
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10.1159/000524399
- URN
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urn:nbn:de:101:1-2022071400312320802308
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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15.08.2025, 7:26 AM CEST
Data provider
This object is provided by:
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- König, David
- Hench, Jürgen
- Frank, Stephan
- Dima, Laura
- Bratic Hench, Ivana
- Läubli, Heinz
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