Canonical and noncanonical functions of complement in systemic lupus erythematosus
Abstract: For many years complement activation in systemic lupus erythematosus (SLE) was viewed as a major cause of tissue injury. However, human and murine studies showed that complement plays a protective as well as a proinflammatory role in tissue damage. A hierarchy is apparent with early classical pathway components, particularly C1q, exerting the greatest influence. Understanding the mechanisms underlying the protective function (s) of complement remains an important challenge for the future and has implications for the use of complement therapy in SLE. We review recent advances in the field and give a new perspective on the complement conundrum in SLE.
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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Canonical and noncanonical functions of complement in systemic lupus erythematosus ; day:17 ; month:04 ; year:2024 ; extent:5
European journal of immunology ; (17.04.2024) (gesamt 5)
- Creator
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Pickering, Matthew C.
Botto, Marina
- DOI
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10.1002/eji.202350918
- URN
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urn:nbn:de:101:1-2404171426056.361714956901
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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14.08.2025, 10:45 AM CEST
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Associated
- Pickering, Matthew C.
- Botto, Marina
Other Objects (12)
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Complement deficiency in pediatric-onset systemic lupus erythematosus
Non-Canonical Grammar!?
Non-canonical lassen-middles
Relations between canonical and non-canonical inflation
Circulating levels of endogenous complement inhibitors correlate inversely with complement consumption in systemic lupus erythematosus
The canonical and non-canonical functions of GRKs
Approximate Entropy in Canonical and Non-Canonical Fiction
Non-canonical inflation in supergravity
Urm1: A Non-Canonical UBL
On non-canonical clause linkage
Peli1 negatively regulates noncanonical NF-κB signaling to restrain systemic lupus erythematosus
Systemischer Lupus erythematosus
Complement deficiency in pediatric-onset systemic lupus erythematosus
Non-Canonical Grammar!?
Non-canonical lassen-middles
Relations between canonical and non-canonical inflation
Circulating levels of endogenous complement inhibitors correlate inversely with complement consumption in systemic lupus erythematosus
The canonical and non-canonical functions of GRKs
Approximate Entropy in Canonical and Non-Canonical Fiction
Non-canonical inflation in supergravity
Urm1: A Non-Canonical UBL
On non-canonical clause linkage
Peli1 negatively regulates noncanonical NF-κB signaling to restrain systemic lupus erythematosus