Canonical and noncanonical functions of complement in systemic lupus erythematosus
Abstract: For many years complement activation in systemic lupus erythematosus (SLE) was viewed as a major cause of tissue injury. However, human and murine studies showed that complement plays a protective as well as a proinflammatory role in tissue damage. A hierarchy is apparent with early classical pathway components, particularly C1q, exerting the greatest influence. Understanding the mechanisms underlying the protective function (s) of complement remains an important challenge for the future and has implications for the use of complement therapy in SLE. We review recent advances in the field and give a new perspective on the complement conundrum in SLE.
- Standort
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Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
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Online-Ressource
- Sprache
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Englisch
- Erschienen in
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Canonical and noncanonical functions of complement in systemic lupus erythematosus ; day:17 ; month:04 ; year:2024 ; extent:5
European journal of immunology ; (17.04.2024) (gesamt 5)
- Urheber
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Pickering, Matthew C.
Botto, Marina
- DOI
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10.1002/eji.202350918
- URN
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urn:nbn:de:101:1-2404171426056.361714956901
- Rechteinformation
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
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14.08.2025, 10:45 MESZ
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Beteiligte
- Pickering, Matthew C.
- Botto, Marina
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