Copper‐Catalyzed Borylative Cross‐Coupling of Allenes and Imines: Selective Three‐Component Assembly of Branched Homoallyl Amines

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Abstract: A copper‐catalyzed three‐component coupling of allenes, bis (pinacolato) diboron, and imines allows regio‐, chemo‐, and diastereoselective assembly of branched α,β‐substituted‐γ‐boryl homoallylic amines, that is, products bearing versatile amino, alkenyl, and borane functionality. Alternatively, convenient oxidative workup allows access to α‐substituted‐β‐amino ketones. A computational study has been used to probe the stereochemical course of the cross‐coupling.

Location: Deutsche Nationalbibliothek Frankfurt am Main

Extent: Online-Ressource

Language: Englisch

Bibliographic citation: Copper‐Catalyzed Borylative Cross‐Coupling of Allenes and Imines: Selective Three‐Component Assembly of Branched Homoallyl Amines ; volume:55 ; number:3 ; year:2016 ; pages:1102-1107 ; extent:6
Angewandte Chemie / International edition. International edition ; 55, Heft 3 (2016), 1102-1107 (gesamt 6)

Creator: Rae, James
Yeung, Kay
McDouall, Joseph J. W.
Procter, David J.

DOI: 10.1002/anie.201508959

URN: urn:nbn:de:101:1-2022110108163754053032

Rights: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.

Last update: 15.08.2025, 7:31 AM CEST

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Associated

Rae, James
Yeung, Kay
McDouall, Joseph J. W.
Procter, David J.

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