Genetic loci associated with heart rate variability and their effects on cardiac disease risk
Abstract: Reduced cardiac vagal control reflected in low heart rate variability (HRV) is associated with greater risks for cardiac morbidity and mortality. In two-stage meta-analyses of genome-wide association studies for three HRV traits in up to 53,174 individuals of European ancestry, we detect 17 genome-wide significant SNPs in eight loci. HRV SNPs tag non-synonymous SNPs (in NDUFA11 and KIAA1755), expression quantitative trait loci (eQTLs) (influencing GNG11, RGS6 and NEO1), or are located in genes preferentially expressed in the sinoatrial node (GNG11, RGS6 and HCN4). Genetic risk scores account for 0.9 to 2.6% of the HRV variance. Significant genetic correlation is found for HRV with heart rate (−0.74
- Standort
-
Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
-
Online-Ressource
- Sprache
-
Englisch
- Anmerkungen
-
Nature communications. - 8 (2017) , 15805, ISSN: 2041-1723
- Ereignis
-
Veröffentlichung
- (wo)
-
Freiburg
- (wer)
-
Universität
- (wann)
-
2021
- Urheber
- DOI
-
10.1038/ncomms15805
- URN
-
urn:nbn:de:bsz:25-freidok-1938168
- Rechteinformation
-
Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
-
25.03.2025, 13:47 MEZ
Datenpartner
Dieses Objekt wird bereitgestellt von:
Deutsche Nationalbibliothek. Bei Fragen zum Objekt wenden Sie sich bitte an den Datenpartner.
Deutsche Nationalbibliothek. Bei Fragen zum Objekt wenden Sie sich bitte an den Datenpartner.
Beteiligte
- Nolte, Ilja M.
- Munoz, M. Loretto
- Tragante, Vinicius
- Li, Yong
- Snieder, Harold
- Geus, Eco J. C. de
- Universität
Entstanden
- 2021
Ähnliche Objekte (12)
Cardiac Autonomic Dysfunction and Incidence of de novo Atrial Fibrillation: Heart Rate Variability vs. Heart Rate Complexity
Decomposition of heart rate variability by adaptive filtering for estimation of cardiac vagal tone
Orthostatic hypotension and heart rate variability as indicators of cardiac autonomic neuropathy in diabetes mellitus
Heart Rate Variability Modulates Interoceptive Accuracy
Quantitative analysis of heart rate variability
Towards Personalized Cardiac Modeling of Failing Heart with Engineered Heart Muscle
Prediction of Sudden Cardiac Death Risk with a Support Vector Machine Based on Heart Rate Variability and Heartprint Indices
Heart of Darkness: Heart Rate Variability on Patients with Risk of Suicide
Heart of Darkness: Heart Rate Variability on Patients with Risk of Suicide
Genetic variability of equine milk protein genes
Mapping the cardiac vascular niche in heart failure
The heart of the matter: cardiac stem cells
Cardiac Autonomic Dysfunction and Incidence of de novo Atrial Fibrillation: Heart Rate Variability vs. Heart Rate Complexity
Decomposition of heart rate variability by adaptive filtering for estimation of cardiac vagal tone
Orthostatic hypotension and heart rate variability as indicators of cardiac autonomic neuropathy in diabetes mellitus
Heart Rate Variability Modulates Interoceptive Accuracy
Quantitative analysis of heart rate variability
Towards Personalized Cardiac Modeling of Failing Heart with Engineered Heart Muscle
Prediction of Sudden Cardiac Death Risk with a Support Vector Machine Based on Heart Rate Variability and Heartprint Indices
Heart of Darkness: Heart Rate Variability on Patients with Risk of Suicide
Heart of Darkness: Heart Rate Variability on Patients with Risk of Suicide
Genetic variability of equine milk protein genes
Mapping the cardiac vascular niche in heart failure
The heart of the matter: cardiac stem cells
Cardiac Autonomic Dysfunction and Incidence of de novo Atrial Fibrillation: Heart Rate Variability vs. Heart Rate Complexity
Decomposition of heart rate variability by adaptive filtering for estimation of cardiac vagal tone
Orthostatic hypotension and heart rate variability as indicators of cardiac autonomic neuropathy in diabetes mellitus
Heart Rate Variability Modulates Interoceptive Accuracy
Quantitative analysis of heart rate variability
Towards Personalized Cardiac Modeling of Failing Heart with Engineered Heart Muscle
Prediction of Sudden Cardiac Death Risk with a Support Vector Machine Based on Heart Rate Variability and Heartprint Indices
Heart of Darkness: Heart Rate Variability on Patients with Risk of Suicide
Heart of Darkness: Heart Rate Variability on Patients with Risk of Suicide
Genetic variability of equine milk protein genes
Mapping the cardiac vascular niche in heart failure