Salivary biomarkers for dental caries detection and personalized monitoring

Abstract: This study investigated the potential of salivary bacterial and protein markers for evaluating the disease status in healthy individuals or patients with gingivitis or caries. Saliva samples from caries- and gingivitis-free individuals (n = 18), patients with gingivitis (n = 17), or patients with deep caries lesions (n = 38) were collected and analyzed for 44 candidate biomarkers (cytokines, chemokines, growth factors, matrix metalloproteinases, a metallopeptidase inhibitor, proteolytic enzymes, and selected oral bacteria). The resulting data were subjected to principal component analysis and used as a training set for random forest (RF) modeling. This computational analysis revealed four biomarkers (IL-4, IL-13, IL-2-RA, and eotaxin/CCL11) to be of high importance for the correct depiction of caries in 37 of 38 patients. The RF model was then used to classify 10 subjects (five caries-/gingivitis-free and five with caries), who were followed over a period of six months. The results were compared to the clinical assessments of dental specialists, revealing a high correlation between the RF prediction and the clinical classification. Due to the superior sensitivity of the RF model, there was a divergence in the prediction of two caries and four caries-/gingivitis-free subjects. These findings suggest IL-4, IL-13, IL-2-RA, and eotaxin/CCL11 as potential salivary biomarkers for identifying noninvasive caries. Furthermore, we suggest a potential association between JAK/STAT signaling and dental caries onset and progression

Standort
Deutsche Nationalbibliothek Frankfurt am Main
Umfang
Online-Ressource
Sprache
Englisch
Anmerkungen
Journal of personalized medicine. - 11, 3 (2021) , 235, ISSN: 2075-4426

Ereignis
Veröffentlichung
(wo)
Freiburg
(wer)
Universität
(wann)
2021
Urheber
Paque, Pune N.
Herz, Christopher
Wiedemeier, Daniel B.
Mitsakakis, Konstantinos
Attin, Thomas
Bao, Kai
Belibasakis, Georgios N.
Hays, John P.
Jenzer, Joël S.
Kaman, Wendy E.
Karpisek, Michal
Körner, Philipp
Peham, Johannes R.
Schmidlin, Patrick Roger
Thurnheer, Thomas
Wegehaupt, Florian J.
Bostanci, Nagihan

DOI
10.3390/jpm11030235
URN
urn:nbn:de:bsz:25-freidok-1941346
Rechteinformation
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Letzte Aktualisierung
14.08.2025, 10:56 MESZ

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  • 2021

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