Salivary biomarkers for dental caries detection and personalized monitoring

Abstract: This study investigated the potential of salivary bacterial and protein markers for evaluating the disease status in healthy individuals or patients with gingivitis or caries. Saliva samples from caries- and gingivitis-free individuals (n = 18), patients with gingivitis (n = 17), or patients with deep caries lesions (n = 38) were collected and analyzed for 44 candidate biomarkers (cytokines, chemokines, growth factors, matrix metalloproteinases, a metallopeptidase inhibitor, proteolytic enzymes, and selected oral bacteria). The resulting data were subjected to principal component analysis and used as a training set for random forest (RF) modeling. This computational analysis revealed four biomarkers (IL-4, IL-13, IL-2-RA, and eotaxin/CCL11) to be of high importance for the correct depiction of caries in 37 of 38 patients. The RF model was then used to classify 10 subjects (five caries-/gingivitis-free and five with caries), who were followed over a period of six months. The results were compared to the clinical assessments of dental specialists, revealing a high correlation between the RF prediction and the clinical classification. Due to the superior sensitivity of the RF model, there was a divergence in the prediction of two caries and four caries-/gingivitis-free subjects. These findings suggest IL-4, IL-13, IL-2-RA, and eotaxin/CCL11 as potential salivary biomarkers for identifying noninvasive caries. Furthermore, we suggest a potential association between JAK/STAT signaling and dental caries onset and progression

Angaben zum Objekt

• Standort: Deutsche Nationalbibliothek Frankfurt am Main
• Umfang: Online-Ressource
• Sprache: Englisch
• Anmerkungen: Journal of personalized medicine. - 11, 3 (2021) , 235, ISSN: 2075-4426

Beteiligte, Orts- und Zeitangaben

• Ereignis: Veröffentlichung
• (wo): Freiburg
• (wer): Universität
• (wann): 2021
• Urheber: Paque, Pune N. ; Herz, Christopher ; Wiedemeier, Daniel B. ; Mitsakakis, Konstantinos ; Attin, Thomas ; Bao, Kai ; Belibasakis, Georgios N. ; Hays, John P. ; Jenzer, Joël S. ; Kaman, Wendy E. ; Karpisek, Michal ; Körner, Philipp ; Peham, Johannes R. ; Schmidlin, Patrick Roger ; Thurnheer, Thomas ; Wegehaupt, Florian J. ; Bostanci, Nagihan

Weitere Informationen

• DOI: 10.3390/jpm11030235
• URN: urn:nbn:de:bsz:25-freidok-1941346
• Rechteinformation: Der Zugriff auf das Objekt ist unbeschränkt möglich.
• Letzte Aktualisierung: 25.03.2025, 13:45 MEZ