Efficacy and safety of pomegranate medicinal products for cancer
Abstract: Preclinical in vitro and in vivo studies demonstrate potent effects of pomegranate preparations in cancer cell lines and animal models with chemically induced cancers. We have carried out one systematic review of the effectiveness of pomegranate products in the treatment of cancer and another on their safety. The PubMed search provided 162 references for pomegranate and cancer and 122 references for pomegranate and safety/toxicity. We identified 4 clinical studies investigating 3 pomegranate products, of which one was inappropriate because of the low polyphenol content. The evidence of clinical effectiveness was poor because the quality of the studies was poor. Although there is no concern over safety with the doses used in the clinical studies, pomegranate preparations may be harmful by inducing synthetic drug metabolism through activation of liver enzymes. We have analysed various pomegranate products for their content of anthocyanins, punicalagin, and ellagic acid in order to compare them with the benchmark doses from published data. If the amount of coactive constituents is not declared, patients risk not benefiting from the putative pomegranate effects. Moreover, pomegranate end products are affected by many determinants. Their declaration should be incorporated into the regulatory guidance and controlled before pomegranate products enter the market
- Standort
-
Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
-
Online-Ressource
- Sprache
-
Englisch
- Anmerkungen
-
Evidence-based complementary and alternative medicine : eCAM. - 2015 (2015) , 1-15, ISSN: 1741-427X
- Ereignis
-
Veröffentlichung
- (wo)
-
Freiburg
- (wer)
-
Universität
- (wann)
-
2019
- Urheber
- Beteiligte Personen und Organisationen
- DOI
-
10.1155/2015/258598
- URN
-
urn:nbn:de:bsz:25-freidok-1256561
- Rechteinformation
-
Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
-
25.03.2025, 13:50 MEZ
Datenpartner
Deutsche Nationalbibliothek. Bei Fragen zum Objekt wenden Sie sich bitte an den Datenpartner.
Beteiligte
- Vlachojannis, Christian
- Zimmermann, Benno F.
- Chrubasik, Sigrun
- Institut für Rechtsmedizin. Freiburg im Breisgau
- Universität
Entstanden
- 2019
Ähnliche Objekte (12)
Guidelines veterinary medicinal products, A.. General, efficacy, environmental risk assessment
Natural products in medicinal chemistry
The safety of fishery products
Guidelines veterinary medicinal products, B.. Immunologicals, quality
Annex 13, investigational medicinal products 2010 : EU guidelines to good manufacturing practice medicinal products for human and veterinary use
Anthroposophic medicinal products: a literature review of features, similarities and differences to conventional medicinal products, scientific and regulatory assessment
Identifikation von Arzneimitteln : = (Identification of medicinal products, IDMP)
Tinzaparin vs. Nadroparin Safety and Efficacy in Neurosurgery
Efficacy and Safety of Irinotecan-Based Chemotherapy for Advanced Colorectal Cancer outside Clinical Trials: An Observational Study
EC guide to good manufacturing practice for medicinal products
EC guide to good manufacturing practice for medicinal products
EC guide to good manufacturing practice for medicinal products
Guidelines veterinary medicinal products, A.. General, efficacy, environmental risk assessment
Natural products in medicinal chemistry
The safety of fishery products
Guidelines veterinary medicinal products, B.. Immunologicals, quality
Annex 13, investigational medicinal products 2010 : EU guidelines to good manufacturing practice medicinal products for human and veterinary use
Anthroposophic medicinal products: a literature review of features, similarities and differences to conventional medicinal products, scientific and regulatory assessment
Identifikation von Arzneimitteln : = (Identification of medicinal products, IDMP)
Tinzaparin vs. Nadroparin Safety and Efficacy in Neurosurgery
Efficacy and Safety of Irinotecan-Based Chemotherapy for Advanced Colorectal Cancer outside Clinical Trials: An Observational Study
EC guide to good manufacturing practice for medicinal products
EC guide to good manufacturing practice for medicinal products
EC guide to good manufacturing practice for medicinal products
Guidelines veterinary medicinal products, A.. General, efficacy, environmental risk assessment
Natural products in medicinal chemistry
The safety of fishery products
Guidelines veterinary medicinal products, B.. Immunologicals, quality
Annex 13, investigational medicinal products 2010 : EU guidelines to good manufacturing practice medicinal products for human and veterinary use
Anthroposophic medicinal products: a literature review of features, similarities and differences to conventional medicinal products, scientific and regulatory assessment
Identifikation von Arzneimitteln : = (Identification of medicinal products, IDMP)
Tinzaparin vs. Nadroparin Safety and Efficacy in Neurosurgery
Efficacy and Safety of Irinotecan-Based Chemotherapy for Advanced Colorectal Cancer outside Clinical Trials: An Observational Study
EC guide to good manufacturing practice for medicinal products
EC guide to good manufacturing practice for medicinal products