Visual field loss and structure-function relationships in optic neuritis associated with myelin oligodendrocyte glycoprotein antibody

Abstract: Background:
A paradoxical discrepancy between severe peripapillary retinal nerve fiber layer (pRNFL) atrophy and good visual outcome had been reported in patients with myelin oligodendrocyte glycoprotein-immunoglobulin G (MOG-IgG)-associated optic neuritis (ON). However, only visual acuity (VA) was assessed.

Objectives:
To study visual field (VF) outcomes of patients with MOG-IgG-associated ON and evaluate the correlation between functional eye outcome and retinal structural changes assessed by optical coherence tomography.

Methods:
The records of 32 patients with MOG-IgG-associated ON who underwent ophthalmological examination at least 12 months after ON onset were reviewed. Degree of VF disability was determined by mean deviation (MD).

Results:
At final assessment (median, 35 months), 4.2% of 48 affected eyes (AE) had VA ⩽ 0.1, 40% had abnormal MD, and among AE with final VA ⩾ 1.0, 31% had mild to moderate damage. Thinning of the inner retinal layers was significantly correlated with MD impairment. Analysis demonstrated a threshold of pRNFL thickness (50 µm), below which MD was significantly worse (mean, −2.27 dB vs −17.72 dB; p = 0.0003). ON relapse was significantly associated with poor visual outcome assessed by MD.

Conclusion:
Functional impairment measured with VF is not rare, and MD assessment better reflects actual structural damage

Angaben zum Objekt

• Standort: Deutsche Nationalbibliothek Frankfurt am Main
• Umfang: Online-Ressource
• Sprache: Englisch
• Anmerkungen: Multiple sclerosis journal. - 27, 6 (2021) , 855-863, ISSN: 1477-0970

Klassifikation und Themen

• Klassifikation: Medizin, Gesundheit

Beteiligte, Orts- und Zeitangaben

• Ereignis: Veröffentlichung
• (wo): Freiburg
• (wer): Universität
• (wann): 2020
• Urheber: Deschamps, Romain ; Philibert, Manon ; Lamirel, Cedric ; Lambert, Jerome ; Vasseur, Vivien ; Gueguen, Antoine ; Bensa, Caroline ; Lecler, Augustin ; Marignier, Romain ; Vignal-Clermont, Catherine ; Gout, Olivier

Weitere Informationen

• DOI: 10.1177/1352458520937281
• URN: urn:nbn:de:bsz:25-freidok-1693787
• Rechteinformation: Kein Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
• Letzte Aktualisierung: 15.08.2025, 07:26 MESZ