Continuous‐Flow Enantioselective Hydroacylations under Heterogeneous Chiral Rhodium Catalysts
Abstract: Transition metal‐catalyzed enantioselective C−H bond functionalizations have become efficient methods for the synthesis of complex optically active molecules. Heterogeneous catalysts for this chemistry remain largely unexplored despite the advantages they offer in terms of ease of separation and reuse of catalysts. Herein, we report the development of heterogeneous chiral Rh catalysts for continuous‐flow enantioselective hydroacylations. Heterogeneous catalysts could be prepared simply by mixing supports and Rh complexes. The prepared catalysts exhibited excellent activity and enantioselectivity affording optically active ketones in quantitative yields with 99 % ee's. Under the optimized reaction conditions, a turnover number >300 was achieved without the leaching of Rh species. The catalysts exhibited a wide substrate scope and in sequential‐flow reactions with other heterogeneous catalysts, the syntheses of biologically active molecules and functional materials were demonstrated.
- Standort
-
Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
-
Online-Ressource
- Sprache
-
Englisch
- Erschienen in
-
Continuous‐Flow Enantioselective Hydroacylations under Heterogeneous Chiral Rhodium Catalysts ; day:22 ; month:11 ; year:2023 ; extent:9
Angewandte Chemie / International edition. International edition ; (22.11.2023) (gesamt 9)
- Urheber
-
Saito, Yuki
Kobayashi, Shū
- DOI
-
10.1002/anie.202313778
- URN
-
urn:nbn:de:101:1-2023112314185399811048
- Rechteinformation
-
Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
-
15.08.2025, 07:28 MESZ
Datenpartner
Deutsche Nationalbibliothek. Bei Fragen zum Objekt wenden Sie sich bitte an den Datenpartner.
Beteiligte
- Saito, Yuki
- Kobayashi, Shū
Ähnliche Objekte (12)
Continuous‐Flow Enantioselective Hydroacylations under Heterogeneous Chiral Rhodium Catalysts
Enantioselective Rhodium-Catalyzed Synthesis of Axially Chiral Biaryls
Rhodium-catalyzed enantioselective and diastereodivergent access to diaxially chiral heterocycles
Rhodium-Catalyzed Enantioselective Desymmetrization
Chiral Cyclopentadienyl Ligands Enable a Rhodium(III)-Catalyzed Enantioselective Access to Hydroxychromanes and Phthalides
Rhodium-Catalyzed Enantioselective Hydroamination of Allenes
Rhodium-Catalyzed Enantioselective Hydroacylation of Ketones
Tailored chiral phosphoramidites support highly enantioselective Pd catalysts for asymmetric aminoalkylative amination
Non‐Covalent Immobilization of Chiral Rhodium Catalysts on Carbon Nanotubes for Asymmetric Hydrogenation
Rhodium-Catalyzed Enantioselective Cycloaddition Route to Indolizidines
Enantioselective Rhodium-Catalyzed Allylation of 2-Pyridones
Rhodium-Catalyzed Enantioselective Hydrogenation of Enamido Esters
Continuous‐Flow Enantioselective Hydroacylations under Heterogeneous Chiral Rhodium Catalysts
Enantioselective Rhodium-Catalyzed Synthesis of Axially Chiral Biaryls
Rhodium-catalyzed enantioselective and diastereodivergent access to diaxially chiral heterocycles
Rhodium-Catalyzed Enantioselective Desymmetrization
Chiral Cyclopentadienyl Ligands Enable a Rhodium(III)-Catalyzed Enantioselective Access to Hydroxychromanes and Phthalides
Rhodium-Catalyzed Enantioselective Hydroamination of Allenes
Rhodium-Catalyzed Enantioselective Hydroacylation of Ketones
Tailored chiral phosphoramidites support highly enantioselective Pd catalysts for asymmetric aminoalkylative amination
Non‐Covalent Immobilization of Chiral Rhodium Catalysts on Carbon Nanotubes for Asymmetric Hydrogenation
Rhodium-Catalyzed Enantioselective Cycloaddition Route to Indolizidines
Enantioselective Rhodium-Catalyzed Allylation of 2-Pyridones
Rhodium-Catalyzed Enantioselective Hydrogenation of Enamido Esters
Continuous‐Flow Enantioselective Hydroacylations under Heterogeneous Chiral Rhodium Catalysts
Enantioselective Rhodium-Catalyzed Synthesis of Axially Chiral Biaryls
Rhodium-catalyzed enantioselective and diastereodivergent access to diaxially chiral heterocycles
Rhodium-Catalyzed Enantioselective Desymmetrization
Chiral Cyclopentadienyl Ligands Enable a Rhodium(III)-Catalyzed Enantioselective Access to Hydroxychromanes and Phthalides
Rhodium-Catalyzed Enantioselective Hydroamination of Allenes
Rhodium-Catalyzed Enantioselective Hydroacylation of Ketones
Tailored chiral phosphoramidites support highly enantioselective Pd catalysts for asymmetric aminoalkylative amination
Non‐Covalent Immobilization of Chiral Rhodium Catalysts on Carbon Nanotubes for Asymmetric Hydrogenation
Rhodium-Catalyzed Enantioselective Cycloaddition Route to Indolizidines
Enantioselective Rhodium-Catalyzed Allylation of 2-Pyridones