Continuous‐Flow Enantioselective Hydroacylations under Heterogeneous Chiral Rhodium Catalysts

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Abstract: Transition metal‐catalyzed enantioselective C−H bond functionalizations have become efficient methods for the synthesis of complex optically active molecules. Heterogeneous catalysts for this chemistry remain largely unexplored despite the advantages they offer in terms of ease of separation and reuse of catalysts. Herein, we report the development of heterogeneous chiral Rh catalysts for continuous‐flow enantioselective hydroacylations. Heterogeneous catalysts could be prepared simply by mixing supports and Rh complexes. The prepared catalysts exhibited excellent activity and enantioselectivity affording optically active ketones in quantitative yields with 99 % ee's. Under the optimized reaction conditions, a turnover number >300 was achieved without the leaching of Rh species. The catalysts exhibited a wide substrate scope and in sequential‐flow reactions with other heterogeneous catalysts, the syntheses of biologically active molecules and functional materials were demonstrated.

Location: Deutsche Nationalbibliothek Frankfurt am Main

Extent: Online-Ressource

Language: Englisch

Bibliographic citation: Continuous‐Flow Enantioselective Hydroacylations under Heterogeneous Chiral Rhodium Catalysts ; day:22 ; month:11 ; year:2023 ; extent:9
Angewandte Chemie / International edition. International edition ; (22.11.2023) (gesamt 9)

Creator: Saito, Yuki
Kobayashi, Shū

DOI: 10.1002/anie.202313778

URN: urn:nbn:de:101:1-2023112314185399811048

Rights: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.

Last update: 15.08.2025, 7:15 AM CEST

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Associated

Saito, Yuki
Kobayashi, Shū

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