Mono‐ and Tri‐Functionalization of Trimethylresorcin (4) arenes

Short and efficient syntheses of mono‐ and tris‐functionalized resorcin[4]arenes were developed. The co‐condensation of resorcinol and 2‐methylresorcinol was optimized, targeting for the trimethylresorcin[4]arene, easy to isolate. Complementary regiospecific conditions for the mono‐ and tris‐halogenation in almost quantitative yields are setting the stage for subsequent functionalizations: radicalic bromination leads to the trisbromomethyl compound, while the polar bromination and iodination via the mono‐lithiated species leads to the aryl bromide and iodide in excellent yields.

Object Details

• Location: Deutsche Nationalbibliothek Frankfurt am Main
• Extent: Online-Ressource
• Language: Englisch

References and Relationships

• Bibliographic citation: Mono‐ and Tri‐Functionalization of Trimethylresorcin (4) arenes ; volume:2020 ; number:1 ; year:2020 ; pages:35-40 ; extent:6 ; European journal of organic chemistry ; 2020, Heft 1 (2020), 35-40 (gesamt 6)

Contributors, Places and Time

• Creator: Loose, Dirk ; Aniol, Alexandra ; Feigel, Martin ; Röhling, Sebastian ; Dyker, Gerald

Further information

• DOI: 10.1002/ejoc.201901564
• URN: urn:nbn:de:101:1-2022062306541838799372
• Rights: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
• Last update: 15.08.2025, 7:23 AM CEST