RAS-ON inhibition overcomes clinical resistance to KRAS G12C-OFF covalent blockade

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Location: Deutsche Nationalbibliothek Frankfurt am Main

Extent: 1 Online-Ressource.

Language: Englisch

Bibliographic citation: RAS-ON inhibition overcomes clinical resistance to KRAS G12C-OFF covalent blockade ; volume:15 ; number:1 ; day:30 ; month:8 ; year:2024 ; pages:1-18 ; date:12.2024
Nature Communications ; 15, Heft 1 (30.8.2024), 1-18, 12.2024

Creator: Nokin, Marie-Julie
Mira, Alessia
Patrucco, Enrico
Ricciuti, Biagio
Cousin, Sophie
Soubeyran, Isabelle
San José, Sonia
Peirone, Serena
Caizzi, Livia
Vietti Michelina, Sandra
Bourdon, Aurelien
Wang, Xinan
Alvarez-Villanueva, Daniel
Martínez-Iniesta, María
Vidal, August
Rodrigues, Telmo
García-Macías, Carmen
Awad, Mark M.
Nadal, Ernest
Villanueva, Alberto
Italiano, Antoine
Cereda, Matteo
Santamaría, David
Ambrogio, Chiara

Contributor: SpringerLink (Online service)

DOI: 10.1038/s41467-024-51828-2

URN: urn:nbn:de:101:1-2411302107593.592611487880

Rights: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.

Last update: 15.08.2025, 7:32 AM CEST

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Associated

Nokin, Marie-Julie
Mira, Alessia
Patrucco, Enrico
Ricciuti, Biagio
Cousin, Sophie
Soubeyran, Isabelle
San José, Sonia
Peirone, Serena
Caizzi, Livia
Vietti Michelina, Sandra
Bourdon, Aurelien
Wang, Xinan
Alvarez-Villanueva, Daniel
Martínez-Iniesta, María
Vidal, August
Rodrigues, Telmo
García-Macías, Carmen
Awad, Mark M.
Nadal, Ernest
Villanueva, Alberto
Italiano, Antoine
Cereda, Matteo
Santamaría, David
Ambrogio, Chiara
SpringerLink (Online service)

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RAS-ON inhibition overcomes clinical resistance to KRAS G12C-OFF covalent blockade

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Other Objects (12)

Drugging the Undruggable using Irreversible Covalent K-Ras G12C Inhibitors

A Ras destabilizer KYA1797K overcomes the resistance of EGFR tyrosine kinase inhibitor in KRAS-mutated non-small cell lung cancer

K-Ras protein as a drug target

Unraveling (K)RAS in pancreatic ductal adenocarcinoma

Restoration of mutant K-Ras repressed miR-199b inhibits K-Ras mutant non-small cell lung cancer progression

K-Ras prenylation as a potential anticancer target

A β-Lactone for Covalent Inhibition of KRAS G12S

AMPK activation overcomes anti-EGFR antibody resistance induced by KRAS mutation in colorectal cancer

An in vivo inflammatory loop potentiates KRAS blockade

TNFα blockade overcomes resistance to anti-PD-1 in experimental melanoma

Covalent Inhibition of Ras G12C with a Stapled Peptidomimetic

Computationally Empowered Workflow Identifies Novel Covalent Allosteric Binders for KRAS G12C

Drugging the Undruggable using Irreversible Covalent K-Ras G12C Inhibitors

A Ras destabilizer KYA1797K overcomes the resistance of EGFR tyrosine kinase inhibitor in KRAS-mutated non-small cell lung cancer

K-Ras protein as a drug target

Unraveling (K)RAS in pancreatic ductal adenocarcinoma

Restoration of mutant K-Ras repressed miR-199b inhibits K-Ras mutant non-small cell lung cancer progression

K-Ras prenylation as a potential anticancer target

A β-Lactone for Covalent Inhibition of KRAS G12S

AMPK activation overcomes anti-EGFR antibody resistance induced by KRAS mutation in colorectal cancer

An in vivo inflammatory loop potentiates KRAS blockade

TNFα blockade overcomes resistance to anti-PD-1 in experimental melanoma

Covalent Inhibition of Ras G12C with a Stapled Peptidomimetic

Computationally Empowered Workflow Identifies Novel Covalent Allosteric Binders for KRAS G12C

Drugging the Undruggable using Irreversible Covalent K-Ras G12C Inhibitors

A Ras destabilizer KYA1797K overcomes the resistance of EGFR tyrosine kinase inhibitor in KRAS-mutated non-small cell lung cancer

K-Ras protein as a drug target

Unraveling (K)RAS in pancreatic ductal adenocarcinoma

Restoration of mutant K-Ras repressed miR-199b inhibits K-Ras mutant non-small cell lung cancer progression

K-Ras prenylation as a potential anticancer target

A β-Lactone for Covalent Inhibition of KRAS G12S

AMPK activation overcomes anti-EGFR antibody resistance induced by KRAS mutation in colorectal cancer

An in vivo inflammatory loop potentiates KRAS blockade

TNFα blockade overcomes resistance to anti-PD-1 in experimental melanoma

Covalent Inhibition of Ras G12C with a Stapled Peptidomimetic

Computationally Empowered Workflow Identifies Novel Covalent Allosteric Binders for KRAS G12C

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