Drugging the Undruggable using Irreversible Covalent K-Ras G12C Inhibitors

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Location: Deutsche Nationalbibliothek Frankfurt am Main

Extent: Online-Ressource

Language: Englisch

Bibliographic citation: Drugging the Undruggable using Irreversible Covalent K-Ras G12C Inhibitors ; volume:17 ; number:09 ; year:2021 ; pages:1055
Synfacts ; 17, Heft 09 (2021), 1055

DOI: 10.1055/s-0040-1720791

URN: urn:nbn:de:101:1-2021090216153049482636

Rights: Kein Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.

Last update: 15.08.2025, 7:35 AM CEST

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Drugging the Undruggable using Irreversible Covalent K-Ras G12C Inhibitors

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Other Objects (12)

Inhibition of Thiol‐Mediated Uptake with Irreversible Covalent Inhibitors

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K-Ras protein as a drug target

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RAS-ON inhibition overcomes clinical resistance to KRAS G12C-OFF covalent blockade

K-Ras protein as a drug target

Unraveling (K)RAS in pancreatic ductal adenocarcinoma

Restoration of mutant K-Ras repressed miR-199b inhibits K-Ras mutant non-small cell lung cancer progression

K-Ras prenylation as a potential anticancer target

A β-Lactone for Covalent Inhibition of KRAS G12S

Combination treatment strategy for pancreatic cancer involving the novel HDAC inhibitor MPT0E028 with a MEK inhibitor beyond K-Ras status

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