Non‐Immunosuppressive Cyclophilin Inhibitors
Abstract: Cyclophilins, enzymes with peptidyl‐prolyl cis/trans isomerase activity, are relevant to a large variety of biological processes. The most abundant member of this enzyme family, cyclophilin A, is the cellular receptor of the immunosuppressive drug cyclosporine A (CsA). As a consequence of the pathophysiological role of cyclophilins, particularly in viral infections, there is a broad interest in cyclophilin inhibition devoid of immunosuppressive activity. This Review first gives an introduction into the physiological and pathophysiological roles of cyclophilins. The presentation of non‐immunosuppressive cyclophilin inhibitors will commence with drugs based on chemical modifications of CsA. The naturally occurring macrocyclic sanglifehrins have become other lead structures for cyclophilin‐inhibiting drugs. Finally, de novo designed compounds, whose structures are not derived from or inspired by natural products, will be presented. Relevant synthetic concepts will be discussed, but the focus will also be on biochemical studies, structure–activity relationships, and clinical studies.
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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Non‐Immunosuppressive Cyclophilin Inhibitors ; day:19 ; month:08 ; year:2022 ; extent:1
Angewandte Chemie / International edition. International edition ; (19.08.2022) (gesamt 1)
- Creator
- DOI
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10.1002/anie.202201597
- URN
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urn:nbn:de:101:1-2022082015040948563547
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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15.08.2025, 7:34 AM CEST
Data provider
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Schiene‐Fischer, Cordelia
- Fischer, Gunter
- Braun, Manfred
Other Objects (12)
Nicht‐immunsuppressive Cyclophilin‐Inhibitoren
Discovery and molecular basis of subtype-selective cyclophilin inhibitors
High-throughput screening and evaluation of isoform specific cyclophilin inhibitors
Gatekeeper Pocket as Auxiliary Interaction Site for Macrocyclic Cyclophilin Inhibitors
Charakterisierung eines neuen extrazellulären Cyclophilin-Inhibitors im Modell der Troponin-induzierten Autoimmunmyokarditis
Pharmacological Cyclophilin inhibitors prevent intoxication of mammalian cells with Bordetella pertussis Toxin
Effects of immunophilin inhibitors and non-immunosuppressive analogs on coronavirus replication in human infection models
Neue Aryl-Ketone als Inhibitoren der Peptidyl-Prolyl-cis/trans-Isomerasen hPin1 und Cyclophilin
The non-immunosuppressive management of childhood nephrotic syndrome
Cyclophilin A interacts with diverse lentiviral capsids
Extracellular cyclophilin A possesses chemotaxic activity in cattle
Cyclophilin B facilitates the replication of Orf virus
Nicht‐immunsuppressive Cyclophilin‐Inhibitoren
Discovery and molecular basis of subtype-selective cyclophilin inhibitors
High-throughput screening and evaluation of isoform specific cyclophilin inhibitors
Gatekeeper Pocket as Auxiliary Interaction Site for Macrocyclic Cyclophilin Inhibitors
Charakterisierung eines neuen extrazellulären Cyclophilin-Inhibitors im Modell der Troponin-induzierten Autoimmunmyokarditis
Pharmacological Cyclophilin inhibitors prevent intoxication of mammalian cells with Bordetella pertussis Toxin
Effects of immunophilin inhibitors and non-immunosuppressive analogs on coronavirus replication in human infection models
Neue Aryl-Ketone als Inhibitoren der Peptidyl-Prolyl-cis/trans-Isomerasen hPin1 und Cyclophilin
The non-immunosuppressive management of childhood nephrotic syndrome
Cyclophilin A interacts with diverse lentiviral capsids
Extracellular cyclophilin A possesses chemotaxic activity in cattle
Cyclophilin B facilitates the replication of Orf virus
Nicht‐immunsuppressive Cyclophilin‐Inhibitoren
Discovery and molecular basis of subtype-selective cyclophilin inhibitors
High-throughput screening and evaluation of isoform specific cyclophilin inhibitors
Gatekeeper Pocket as Auxiliary Interaction Site for Macrocyclic Cyclophilin Inhibitors
Charakterisierung eines neuen extrazellulären Cyclophilin-Inhibitors im Modell der Troponin-induzierten Autoimmunmyokarditis
Pharmacological Cyclophilin inhibitors prevent intoxication of mammalian cells with Bordetella pertussis Toxin
Effects of immunophilin inhibitors and non-immunosuppressive analogs on coronavirus replication in human infection models
Neue Aryl-Ketone als Inhibitoren der Peptidyl-Prolyl-cis/trans-Isomerasen hPin1 und Cyclophilin
The non-immunosuppressive management of childhood nephrotic syndrome
Cyclophilin A interacts with diverse lentiviral capsids
Extracellular cyclophilin A possesses chemotaxic activity in cattle