Controlled co‐immobilization of biomolecules on quinone‐bearing plasma polymer films for multifunctional biomaterial surfaces

Abstract: In this study, an efficient methodology, allowing the controlled co‐immobilization of two complementary biomolecules, is reported for the production of multifunctional antibacterial surfaces. To promote long‐lasting covalent immobilization, metallic surfaces are first coated with a quinone‐bearing poly (methacrylate)‐based thin film by combining an atmospheric pressure liquid‐assisted plasma polymerization and a controlled sodium periodate‐induced catechol oxidation steps. The influence of the oxidation step on the film morphology and chemistry is investigated using an analytical multitool approach involving atomic force microscopy, ultraviolet, infrared, and X‐ray photoelectron spectroscopy techniques. Quartz crystal microbalance with dissipation monitoring (QCM‐D) analyses allow the rapid determination of the optimal biomolecule immobilization conditions in terms of kinetics of grafting and biomolecule solution concentrations. In vitro functional assays combined with QCM‐D analyses demonstrate promising, dual biologically active coated surfaces.

Object Details

• Location: Deutsche Nationalbibliothek Frankfurt am Main
• Extent: Online-Ressource
• Language: Englisch

References and Relationships

• Bibliographic citation: Controlled co‐immobilization of biomolecules on quinone‐bearing plasma polymer films for multifunctional biomaterial surfaces ; volume:17 ; number:11 ; year:2020 ; extent:13 ; Plasma processes and polymers ; 17, Heft 11 (2020) (gesamt 13)

Contributors, Places and Time

• Creator: Czuba, Urszula ; Moreno‐Couranjou, Maryline ; Collard, Delphine ; De Pauw‐Gillet, Marie‐Claire ; Quintana, Robert ; Lassaux, Patricia ; Detrembleur, Christophe ; Choquet, Patrick

Further information

• DOI: 10.1002/ppap.202000090
• URN: urn:nbn:de:101:1-2022062811321603625492
• Rights: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
• Last update: 15.08.2025, 7:31 AM CEST