Switch of intravitreal therapy for macular edema secondary to retinal vein occlusion from Anti-VEGF to dexamethasone implant and vice versa

Abstract: Purpose. To evaluate the anatomical and functional outcome of intravitreal dexamethasone implant for macular edema secondaryto central (C) or branch (B) retinal vein occlusion (RVO) in patients with persistent macular edema (ME) refractory to intravitrealantivascular endothelial growth factor (VEGF) treatment compared to treatment naïve patients and to dexamethasone-refractoryeyes switched to anti-VEGF.Methods. Retrospective, observational study including 30 eyes previously treated with anti-VEGF(8 CRVO, 22 BRVO, mean age 69±10 yrs), compared to 11 treatment naïve eyes (6 CRVO, 5 BRVO, 73±11 yrs) andcompared to dexamethasone nonresponders (2 CRVO, 4 BRVO, 69±12). Outcome parameters were change in best-corrected visual acuity (BCVA) and central foveal thickness (CFT) measured by spectral-domain optical coherencetomography.Results. Mean BCVA improvement after switch to dexamethasone implant was 4 letters (p=008), andtreatment naïve eyes gained 10 letters (p=066), while we noted no change in eyes after switch to anti-VEGF (p=074).Median CFT decrease was most pronounced in treatment naïve patients (−437μm,p=0002) compared to anti-VEGFrefractory eyes (−170μm,p=0003) and dexamethasone-refractory eyes (−157,p=031).Conclusions. Dexamethasonesignificantly reduced ME secondary to RVO refractory to anti-VEGF. Functional gain was limited compared to treatmentnaïve eyes, probably due to worse BCVA and CFT at baseline in treatment naïve eyes

Angaben zum Objekt

• Standort: Deutsche Nationalbibliothek Frankfurt am Main
• Umfang: Online-Ressource
• Sprache: Englisch
• Anmerkungen: Journal of ophthalmology. - 2017 (2017) , 1-7, ISSN: 2090-004X

Beteiligte, Orts- und Zeitangaben

• Ereignis: Veröffentlichung
• (wo): Freiburg
• (wer): Universität
• (wann): 2019
• Urheber: Pielen, Amelie ; Bühler, Anima Désirée ; Heinzelmann-Mink, Sonja Ute ; Böhringer, Daniel ; Neß, Thomas ; Junker, Bernd
• Beteiligte Personen und Organisationen: Abteilung Allgemeine Augenheilkunde mit Poliklinik

Weitere Informationen

• DOI: 10.1155/2017/5831682
• URN: urn:nbn:de:bsz:25-freidok-1408923
• Rechteinformation: Kein Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
• Letzte Aktualisierung: 14.08.2025, 10:55 MESZ