Chemoenzymatic Total Synthesis of Sorbicatechol Structural Analogues and Evaluation of Their Antiviral Potential
Abstract: Sorbicillinoids are fungal polyketides characterized by highly complex and diverse molecular structures, with considerable stereochemical intricacy combined with a high degree of oxygenation. Many sorbicillinoids possess promising biological activities. An interesting member of this natural product family is sorbicatechol A, which is reported to have antiviral activity, particularly against influenza A virus (H1N1). Through a straightforward, one‐pot chemoenzymatic approach with recently developed oxidoreductase SorbC, the characteristic bicyclo[2.2.2]octane core of sorbicatechol is structurally diversified by variation of its natural 2‐methoxyphenol substituent. This facilitates the preparation of a focused library of structural analogues bearing substituted aromatic systems, alkanes, heterocycles, and ethers. Fast access to this structural diversity provides an opportunity to explore the antiviral potential of the sorbicatechol family.
- Standort
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Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
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Online-Ressource
- Sprache
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Englisch
- Erschienen in
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Chemoenzymatic Total Synthesis of Sorbicatechol Structural Analogues and Evaluation of Their Antiviral Potential ; volume:21 ; number:4 ; year:2020 ; pages:492-495 ; extent:4
ChemBioChem ; 21, Heft 4 (2020), 492-495 (gesamt 4)
- Urheber
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Sib, Anna
Milzarek, Tobias M.
Herrmann, Alexander
Oubraham, Lila
Müller, Jonas I.
Pichlmair, Andreas
Brack‐Werner, Ruth
Gulder, Tobias A. M.
- DOI
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10.1002/cbic.201900472
- URN
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urn:nbn:de:101:1-2022062006192264010618
- Rechteinformation
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
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15.08.2025, 07:36 MESZ
Datenpartner
Deutsche Nationalbibliothek. Bei Fragen zum Objekt wenden Sie sich bitte an den Datenpartner.
Beteiligte
- Sib, Anna
- Milzarek, Tobias M.
- Herrmann, Alexander
- Oubraham, Lila
- Müller, Jonas I.
- Pichlmair, Andreas
- Brack‐Werner, Ruth
- Gulder, Tobias A. M.
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