Total Synthesis of Anti‐MRSA Active Diorcinols and Analogues

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Abstract: Diorcinols and related prenylated diaryl ethers were reported to exhibit activity against methicillin‐resistant clinical isolates of Staphylococcus aureus (MRSA). Within these lines, we report the first total synthesis of diorcinol D, I, J, the proposed structure of verticilatin and recently isolated antibacterial diaryl ether by using an efficient and highly divergent synthetic strategy. These total syntheses furnish the diaryl ethers in only five to seven steps employing a Pd‐catalyzed diaryl ether coupling as the key step. The total synthesis led to the structural revision of the natural product verticilatin, which has been isolated from a plant pathogenic fungus. Furthermore, these structures were tested in order to determine their antibacterial activities against different MRSA strains as well as further Gram‐positive and ‐negative bacteria.

Standort
Deutsche Nationalbibliothek Frankfurt am Main
Umfang
Online-Ressource
Sprache
Englisch

Erschienen in
Total Synthesis of Anti‐MRSA Active Diorcinols and Analogues ; volume:26 ; number:44 ; year:2020 ; pages:9846-9850 ; extent:5
Chemistry - a European journal ; 26, Heft 44 (2020), 9846-9850 (gesamt 5)

Urheber
Boehlich, G. Jacob
de Vries, Jessica
Geismar, Olivia
Gudzuhn, Mirja
Streit, Wolfgang R.
Wicha, Sebastian Georg
Schützenmeister, Nina

DOI
10.1002/chem.202002442
URN
urn:nbn:de:101:1-2022060417020037164825
Rechteinformation
Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
Letzte Aktualisierung
15.08.2025, 07:35 MESZ

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