Pomalidomide combinations are a safe and effective option after daratumumab failure

Abstract: Purpose
Outcomes of multiple myeloma (MM) patients who are refractory to daratumumab are dismal and no standard of treatment exists for this patients’ population. Here, we investigate the role of pomalidomide combinations in daratumumab-refractory MM patients.

Methods
We performed a retrospective analysis of myeloma patients treated at four referral centers (three in Germany and one in Italy). Review chart identified 30 patients with relapsed and refractory myeloma, who progressed during treatment with daratumumab and were treated with pomalidomide-based combinations in the subsequent lines of therapy.

Results
Responses improved from 37% with daratumumab to 53% with pomalidomide. Of seven patients with extramedullary MM (EMM), four achieved a clinical stabilization with pomalidomide, including one patient with a long-lasting complete response. Median progression-free survival and overall survival were 6 and 12 months, respectively. Pomalidomide combinations were well tolerated, no patient discontinued treatment due to adverse events.

Conclusion
These data show that pomalidomide-based combinations can be an effective and safe salvage regimen for daratumumab-refractory patients, including those with EMM

Angaben zum Objekt

• Standort: Deutsche Nationalbibliothek Frankfurt am Main
• Umfang: Online-Ressource
• Sprache: Englisch
• Anmerkungen: ournal of cancer research and clinical oncology. - 149, 9 (2023) , 6569-6574, ISSN: 1432-1335

Beteiligte, Orts- und Zeitangaben

• Ereignis: Veröffentlichung
• (wo): Freiburg
• (wer): Universität
• (wann): 2024
• Urheber: Brioli, Annamaria ; Gengenbach, Laura Sophie ; Mancuso, Katia ; Binder, Mascha ; Ernst, Thomas ; Heidel, Florian ; Stauch, Thomas ; Zamagni, Elena ; Hilgendorf, Inken ; Hochhaus, Andreas ; Engelhardt, Monika ; Lilienfeld-Toal, Marie von

Weitere Informationen

• DOI: 10.1007/s00432-023-04637-x
• URN: urn:nbn:de:bsz:25-freidok-2437246
• Rechteinformation: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
• Letzte Aktualisierung: 15.08.2025, 07:35 MESZ