Echinocandins: structural diversity, biosynthesis, and development of antimycotics
Abstract: Echinocandins are a clinically important class of non-ribosomal antifungal lipopeptides produced by filamentous fungi. Due to their complex structure, which is characterized by numerous hydroxylated non-proteinogenic amino acids, echinocandin antifungal agents are manufactured semisynthetically. The development of optimized echinocandin structures is therefore closely connected to their biosynthesis. Enormous efforts in industrial research and development including fermentation, classical mutagenesis, isotope labeling, and chemical synthesis eventually led to the development of the active ingredients caspofungin, micafungin, and anidulafungin, which are now used as first-line treatments against invasive mycosis. In the last years, echinocandin biosynthetic gene clusters have been identified, which allowed for the elucidation but also engineering of echinocandin biosynthesis on the molecular level. After a short description of the history of echinocandin research, this review provides an overview of the current knowledge of echinocandin biosynthesis with a special focus of the diverse structural elements, their biosynthetic background, and structure−activity relationships
- Location
-
Deutsche Nationalbibliothek Frankfurt am Main
- Extent
-
Online-Ressource
- Language
-
Englisch
- Notes
-
Applied microbiology and biotechnology. - 105, 1 (2021) , 55-66, ISSN: 1432-0614
- Classification
-
Chemie
- DOI
-
10.1007/s00253-020-11022-y
- URN
-
urn:nbn:de:bsz:25-freidok-1753238
- Rights
-
Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
- 15.08.2025, 7:23 AM CEST
Data provider
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Hüttel, Wolfgang
- Universität
Time of origin
- 2021
Other Objects (12)
Structural diversity, bioactivity, and biosynthesis of phosphoglycolipid family antibiotics: Recent advances
Structural and taxonomic diversity predict above‐ground biomass better than functional measures of maximum height in mixed‐species forests
Global data on earthworm abundance, biomass, diversity and corresponding environmental properties
Structural priors represented by discrete cosine transform improve EIT functional imaging
Diversity as democratic intervention : : the intermediation of diversity and egalitarian participation and its critique
Climate and soil effects on tree species diversity and aboveground carbon patterns in semi-arid tree savannas
Religious plurality and diversity in secular Europe
Biocatalytic diversity of Fe(II) and 2-Oxoglutarate dependent enzymes of the carnitine biosynthesis
Influence of harvesting intensity on species and structural diversity of forests
SDR-catalyzed redox reactions: structural insights into biosynthetic and biocatalytic diversity
Cultural diversity, biodiversity conservation, and modern identity: Conflicts about biocultural diversity in Thung Yai, a world heritage site in Thailand
Development of bioinformatic methods for the prediction and understanding of biosynthesis and activity of natural products
Structural diversity, bioactivity, and biosynthesis of phosphoglycolipid family antibiotics: Recent advances
Structural and taxonomic diversity predict above‐ground biomass better than functional measures of maximum height in mixed‐species forests
Global data on earthworm abundance, biomass, diversity and corresponding environmental properties
Structural priors represented by discrete cosine transform improve EIT functional imaging
Diversity as democratic intervention : : the intermediation of diversity and egalitarian participation and its critique
Climate and soil effects on tree species diversity and aboveground carbon patterns in semi-arid tree savannas
Religious plurality and diversity in secular Europe
Biocatalytic diversity of Fe(II) and 2-Oxoglutarate dependent enzymes of the carnitine biosynthesis
Influence of harvesting intensity on species and structural diversity of forests
SDR-catalyzed redox reactions: structural insights into biosynthetic and biocatalytic diversity
Cultural diversity, biodiversity conservation, and modern identity: Conflicts about biocultural diversity in Thung Yai, a world heritage site in Thailand
Development of bioinformatic methods for the prediction and understanding of biosynthesis and activity of natural products
Structural diversity, bioactivity, and biosynthesis of phosphoglycolipid family antibiotics: Recent advances
Structural and taxonomic diversity predict above‐ground biomass better than functional measures of maximum height in mixed‐species forests
Global data on earthworm abundance, biomass, diversity and corresponding environmental properties
Structural priors represented by discrete cosine transform improve EIT functional imaging
Diversity as democratic intervention : : the intermediation of diversity and egalitarian participation and its critique
Climate and soil effects on tree species diversity and aboveground carbon patterns in semi-arid tree savannas
Religious plurality and diversity in secular Europe
Biocatalytic diversity of Fe(II) and 2-Oxoglutarate dependent enzymes of the carnitine biosynthesis
Influence of harvesting intensity on species and structural diversity of forests
SDR-catalyzed redox reactions: structural insights into biosynthetic and biocatalytic diversity
Cultural diversity, biodiversity conservation, and modern identity: Conflicts about biocultural diversity in Thung Yai, a world heritage site in Thailand