Nitric Acid Promoted Metal-Free Bromothiolation of Internal Alkynes with Hydrobromic Acid and Disulfides

A novel, metal-free bromo-thiolation of internal alkynes with hydrobromic acid and disulfides has been developed. The reaction is promoted by commercial-grade nitric acid and is used to construct a series of unexplored β-bromoalkenyl sulfides in moderate to good yield. Most products were obtained with high stereoselectivity as syn-configured tetrasubstituted alkenes. Both sulfide groups of the disulfide reagent were used in this method.

Object Details

• Location: Deutsche Nationalbibliothek Frankfurt am Main
• Extent: Online-Ressource
• Language: Englisch

References and Relationships

• Bibliographic citation: Nitric Acid Promoted Metal-Free Bromothiolation of Internal Alkynes with Hydrobromic Acid and Disulfides ; volume:33 ; number:15 ; year:2022 ; pages:1539-1545 ; Synlett ; 33, Heft 15 (2022), 1539-1545

Contributors, Places and Time

• Contributor: Sun, Han ; Huang, Xiao-Cheng ; Yao, Zhi-Xiang ; Su, Hui

Further information

• DOI: 10.1055/s-0040-1719934
• URN: urn:nbn:de:101:1-2022111010470986096261
• Rights: Kein Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
• Last update: 15.08.2025, 7:35 AM CEST