Glucose/Furfural Substrate Mixtures in Non‐Engineered Yeast: Potential for Massive Rerouting of Fermentation to C−C Bond Formation on Furfural
Abstract: Suitable mixtures of glucose and furfural may provide novel strategies for C−C bond formation on furfural due to the versatility of low‐cost biological catalysts. We use in‐cell NMR with non‐engineered commercial yeast as the catalyst to determine the interplay between furfural and glucose metabolism in non‐engineered yeast. The presence of furfural is shown to modulate kinetic barriers in glucose conversion and to favor the accumulation of acetaldehyde in situ. As a result, glucose carbons are remarkably strongly redirected towards C−C bond formation between furfural and a glucose‐derived C2 unit. In the presence of suitable glucose/furfural substrate mixtures in non‐engineered yeasts, glucose carbons can achieve relative influxes of at least 80 % into the C−C bond formation on furfural, compared to only 20 % into ethanol. Chain‐elongation of furfural by yeast thus seems a viable strategy for the upgrading of lignocellulosic biomass through concurrent conversion of furfural and glucose. The product is related to chemicals that already have found value in the fine chemical and pharmaceutical industries.
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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Glucose/Furfural Substrate Mixtures in Non‐Engineered Yeast: Potential for Massive Rerouting of Fermentation to C−C Bond Formation on Furfural ; day:27 ; month:11 ; year:2022 ; extent:1
ChemCatChem ; (27.11.2022) (gesamt 1)
- Creator
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Sannelli, Francesca
Gao, Sanni
Jensen, Pernille Rose
Meier, Sebastian
- DOI
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10.1002/cctc.202200933
- URN
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urn:nbn:de:101:1-2022112814083454676023
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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15.08.2025, 7:25 AM CEST
Data provider
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Sannelli, Francesca
- Gao, Sanni
- Jensen, Pernille Rose
- Meier, Sebastian
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Molecular mechanism of engineered Zymomonas mobilis to furfural and acetic acid stress
Biochar-mediated enhanced ethanol fermentation (BMEEF) in Zymomonas mobilis under furfural and acetic acid stress
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Hydroxymethylfurfural und Furfural in Röstgetränken
Preparation of furfural and reaction kinetics of xylose dehydration to furfural in high-temperature water
Molecular mechanism of engineered Zymomonas mobilis to furfural and acetic acid stress
Biochar-mediated enhanced ethanol fermentation (BMEEF) in Zymomonas mobilis under furfural and acetic acid stress
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Improving furfural tolerance in a xylose-fermenting yeast Spathaspora passalidarum CMUWF1–2 via adaptive laboratory evolution
Homogeneous Catalyzed Direct Conversion of Furfural to Gamma‐Valerolactone
Intensifying Cyclopentanone Synthesis from Furfural Using Supported Copper Catalysts
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