In vitro Hemostatic Functions of Cold-Stored Platelets

Background: Transfusion of platelets is a life-saving medical strategy used worldwide to treat patients with thrombocytopenia as well as platelet function disorders. Summary: Until the end of 1960s, platelets were stored in the cold because of their superior hemostatic functionality. Cold storage of platelets was then abandoned due to better posttransfusion recovery and survival of room temperature (RT)-stored platelets, demonstrated by radioactive labeling studies. Based on these findings, RT became the standard condition to store platelets for clinical applications. Evidence shows that RT storage increases the risk of septic transfusion reactions associated with bacterial contamination. Therefore, the storage time is currently limited to 4–7 days, according to the national guidelines, causing a constant challenge to cover the clinical request. Despite the enormous efforts made to optimize storage conditions of platelets, the quality and efficacy of platelets still decrease during the short storage time at RT. In this context, during the last years, cold storage has seen a renaissance due to the better hemostatic functionality, reduced risk of bacterial contamination, and potentially longer storage time. Key Messages: In this review, we will focus on the impact of cold storage on the in vitro platelet functions as promising alternative storage temperature for future medical applications.

Standort
Deutsche Nationalbibliothek Frankfurt am Main
Umfang
Online-Ressource
Sprache
Englisch

Erschienen in
In vitro Hemostatic Functions of Cold-Stored Platelets ; volume:51 ; number:2 ; year:2023 ; pages:94-100 ; extent:7
Transfusion medicine and hemotherapy ; 51, Heft 2 (2023), 94-100 (gesamt 7)

Urheber
Kirschall, Johanna
Uzun, Günalp
Bakchoul, Tamam
Marini, Irene

DOI
10.1159/000533735
URN
urn:nbn:de:101:1-2024041101382985480892
Rechteinformation
Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
Letzte Aktualisierung
14.08.2025, 10:54 MESZ

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Beteiligte

  • Kirschall, Johanna
  • Uzun, Günalp
  • Bakchoul, Tamam
  • Marini, Irene

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