In vitro Hemostatic Functions of Cold-Stored Platelets
Background: Transfusion of platelets is a life-saving medical strategy used worldwide to treat patients with thrombocytopenia as well as platelet function disorders. Summary: Until the end of 1960s, platelets were stored in the cold because of their superior hemostatic functionality. Cold storage of platelets was then abandoned due to better posttransfusion recovery and survival of room temperature (RT)-stored platelets, demonstrated by radioactive labeling studies. Based on these findings, RT became the standard condition to store platelets for clinical applications. Evidence shows that RT storage increases the risk of septic transfusion reactions associated with bacterial contamination. Therefore, the storage time is currently limited to 4–7 days, according to the national guidelines, causing a constant challenge to cover the clinical request. Despite the enormous efforts made to optimize storage conditions of platelets, the quality and efficacy of platelets still decrease during the short storage time at RT. In this context, during the last years, cold storage has seen a renaissance due to the better hemostatic functionality, reduced risk of bacterial contamination, and potentially longer storage time. Key Messages: In this review, we will focus on the impact of cold storage on the in vitro platelet functions as promising alternative storage temperature for future medical applications.
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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In vitro Hemostatic Functions of Cold-Stored Platelets ; volume:51 ; number:2 ; year:2023 ; pages:94-100 ; extent:7
Transfusion medicine and hemotherapy ; 51, Heft 2 (2023), 94-100 (gesamt 7)
- Creator
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Kirschall, Johanna
Uzun, Günalp
Bakchoul, Tamam
Marini, Irene
- DOI
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10.1159/000533735
- URN
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urn:nbn:de:101:1-2024041101382985480892
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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14.08.2025, 10:54 AM CEST
Data provider
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Kirschall, Johanna
- Uzun, Günalp
- Bakchoul, Tamam
- Marini, Irene
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The in Vivo Evaluation of the Hemostatic Function of Stored Human Platelets
The Functionality of Cold-stored Platelets with Apoptosis Inhibition
The Non-Hemostatic Aspects of Transfused Platelets
Increased Responsiveness of Stored Platelets after Short-Term Refrigeration
In vitro properties of concentrated canine platelets stored in two additive solutions: a comparative study
Production of cold electron beams for collision experiments with stored ions
Production of cold electron beams for collision experiments with stored ions
Occurrence of Rhexocercosporidium carotae on cold stored carrot roots in the Netherlands
Delayed cold-stored vs. room temperature stored platelet transfusions in bleeding adult cardiac surgery patients—a randomized multicentre pilot study (PLTS-1)
Platelets – Molecular, cellular and systemic functions in health and disease
The haemostatic effect of deep-frozen platelets versus room temperature-stored platelets in the treatment of surgical bleeding: MAFOD—study protocol for a randomized controlled non-inferiority trial
Flavour Stability of a Cold-Stored Unpasteurized Low-Alcohol Beer Produced by Saccharomycodes ludwigii
The in Vivo Evaluation of the Hemostatic Function of Stored Human Platelets
The Functionality of Cold-stored Platelets with Apoptosis Inhibition
The Non-Hemostatic Aspects of Transfused Platelets
Increased Responsiveness of Stored Platelets after Short-Term Refrigeration
In vitro properties of concentrated canine platelets stored in two additive solutions: a comparative study
Production of cold electron beams for collision experiments with stored ions
Production of cold electron beams for collision experiments with stored ions
Occurrence of Rhexocercosporidium carotae on cold stored carrot roots in the Netherlands
Delayed cold-stored vs. room temperature stored platelet transfusions in bleeding adult cardiac surgery patients—a randomized multicentre pilot study (PLTS-1)
Platelets – Molecular, cellular and systemic functions in health and disease
The haemostatic effect of deep-frozen platelets versus room temperature-stored platelets in the treatment of surgical bleeding: MAFOD—study protocol for a randomized controlled non-inferiority trial