Enhanced Drug Delivery with Oil‐in‐Water Nanoemulsions: Stability and Sustained Release of Doxorubicin
Abstract: In this study, oil‐in‐water nanoemulsions are prepared, an isotropic mixture of oil, surfactant, and cosurfactants. The nanoemulsions exhibit stable structures and are capable of efficiently encapsulating hydrophobic drugs such as doxorubicin (Dox). Compared to polymeric micelles, nanoemulsions demonstrate enhanced stability and loading capacity for Dox. Furthermore, nanoemulsions release Dox steadily over 14 days, with 51.6% released within the initial 24 h and up to 80% over the subsequent period. These properties suggest that nanoemulsions can mitigate the side effects related to the burst release of Dox, thereby improving therapeutic efficacy and safety. Additionally, nanoemulsion‐treated cardiomyocytes show increased viability compared to those treated with free Dox, indicating the potential of nanoemulsions to alleviate Dox‐induced cardiotoxicity. Overall, nanoemulsions hold promise as versatile and efficient drug carriers for improving cancer treatment outcomes.
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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Enhanced Drug Delivery with Oil‐in‐Water Nanoemulsions: Stability and Sustained Release of Doxorubicin ; day:31 ; month:07 ; year:2024 ; extent:5
Macromolecular rapid communications ; (31.07.2024) (gesamt 5)
- Creator
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Hwang, Juyoung
Park, Ji Yeong
Kang, Jio
Oh, Nuri
Li, Chen
Yoo, Chung‐Yul
Um, Wooram
Kwak, Minseok
- DOI
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10.1002/marc.202400480
- URN
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urn:nbn:de:101:1-2408011406496.135069443842
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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14.08.2025, 10:58 AM CEST
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Associated
- Hwang, Juyoung
- Park, Ji Yeong
- Kang, Jio
- Oh, Nuri
- Li, Chen
- Yoo, Chung‐Yul
- Um, Wooram
- Kwak, Minseok
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