Combined inhibition of EZH2 and ATM is synthetic lethal in BRCA1-deficient breast cancer

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Location: Deutsche Nationalbibliothek Frankfurt am Main

ISSN: 1465-542X

Extent: Online-Ressource

Language: Englisch

Notes: online resource.

Bibliographic citation: Combined inhibition of EZH2 and ATM is synthetic lethal in BRCA1-deficient breast cancer ; volume:24 ; number:1 ; day:17 ; month:6 ; year:2022 ; pages:1-19 ; date:12.2022
Breast cancer research ; 24, Heft 1 (17.6.2022), 1-19, 12.2022

Creator: Ratz, Leonie
Brambillasca, Chiara
Bartke, Leandra
Huetzen, Maxim A.
Goergens, Jonas
Leidecker, Orsolya
Jachimowicz, Ron D.
Ven, Marieke van de
Proost, Natalie
Siteur, Bjørn
Korte-Grimmerink, Renske de
Bouwman, Peter
Pulver, Emilia M.
Bruijn, Roebi de
Isensee, Jörg
Hucho, Tim
Pandey, Gaurav
Lohuizen, Maarten van
Mallmann, Peter
Reinhardt, Hans Christian
Jonkers, Jos
Puppe, Julian

Contributor: SpringerLink (Online service)

DOI: 10.1186/s13058-022-01534-y

URN: urn:nbn:de:101:1-2022081623423750917206

Rights: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.

Last update: 15.08.2025, 7:25 AM CEST

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Associated

Ratz, Leonie
Brambillasca, Chiara
Bartke, Leandra
Huetzen, Maxim A.
Goergens, Jonas
Leidecker, Orsolya
Jachimowicz, Ron D.
Ven, Marieke van de
Proost, Natalie
Siteur, Bjørn
Korte-Grimmerink, Renske de
Bouwman, Peter
Pulver, Emilia M.
Bruijn, Roebi de
Isensee, Jörg
Hucho, Tim
Pandey, Gaurav
Lohuizen, Maarten van
Mallmann, Peter
Reinhardt, Hans Christian
Jonkers, Jos
Puppe, Julian
SpringerLink (Online service)

Other Objects (12)

Combination of EZH2 and ATM inhibition in BAP1-deficient mesothelioma

Drug combination studies of EZH2 inhibition combined with ATM, PI3-Kinase and CDK inhibitors in BRCA1-deficient breast tumors

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BRCA1 deficient mammary tumors are dependent on EZH2 expression and sensitive to polycomp repressive complex 2-inhibitor 3-deazaneplanocin A

BRCA1-deficient mammary tumor cells are dependent on EZH2 expression and sensitive to Polycomb Repressive Complex 2-inhibitor 3-deazaneplanocin A

Inhibition of ATM kinase rescues planarian regeneration after lethal radiation

Funktionelle und mechanistische Charakterisierung von EZH2 in Atm-defizienten Subtypen des Pankreaskarzinoms

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The biology and molecular vulnerabilities of ATM-deficient cancers

PARG deficiency is neither synthetic lethal with BRCA1 nor PTEN deficiency

Polθ: emerging synthetic lethal partner in homologous recombination-deficient tumors

Mechanisms of increased risk of tumorigenesis in Atm and Brca1 double heterozygosity

Ibuprofen prevents progression of ataxia telangiectasia symptoms in ATM-deficient mice

Gadd45a deletion aggravates hematopoietic stem cell dysfunction in ATM-deficient mice

Combination of EZH2 and ATM inhibition in BAP1-deficient mesothelioma

Drug combination studies of EZH2 inhibition combined with ATM, PI3-Kinase and CDK inhibitors in BRCA1-deficient breast tumors

Hochschulschrift

BRCA1 deficient mammary tumors are dependent on EZH2 expression and sensitive to polycomp repressive complex 2-inhibitor 3-deazaneplanocin A

BRCA1-deficient mammary tumor cells are dependent on EZH2 expression and sensitive to Polycomb Repressive Complex 2-inhibitor 3-deazaneplanocin A

Inhibition of ATM kinase rescues planarian regeneration after lethal radiation

Funktionelle und mechanistische Charakterisierung von EZH2 in Atm-defizienten Subtypen des Pankreaskarzinoms

Hochschulschrift

The biology and molecular vulnerabilities of ATM-deficient cancers

PARG deficiency is neither synthetic lethal with BRCA1 nor PTEN deficiency

Polθ: emerging synthetic lethal partner in homologous recombination-deficient tumors

Mechanisms of increased risk of tumorigenesis in Atm and Brca1 double heterozygosity

Ibuprofen prevents progression of ataxia telangiectasia symptoms in ATM-deficient mice

Gadd45a deletion aggravates hematopoietic stem cell dysfunction in ATM-deficient mice

Combination of EZH2 and ATM inhibition in BAP1-deficient mesothelioma

Drug combination studies of EZH2 inhibition combined with ATM, PI3-Kinase and CDK inhibitors in BRCA1-deficient breast tumors

Hochschulschrift

BRCA1 deficient mammary tumors are dependent on EZH2 expression and sensitive to polycomp repressive complex 2-inhibitor 3-deazaneplanocin A

BRCA1-deficient mammary tumor cells are dependent on EZH2 expression and sensitive to Polycomb Repressive Complex 2-inhibitor 3-deazaneplanocin A

Inhibition of ATM kinase rescues planarian regeneration after lethal radiation

Funktionelle und mechanistische Charakterisierung von EZH2 in Atm-defizienten Subtypen des Pankreaskarzinoms

Hochschulschrift

The biology and molecular vulnerabilities of ATM-deficient cancers

PARG deficiency is neither synthetic lethal with BRCA1 nor PTEN deficiency

Polθ: emerging synthetic lethal partner in homologous recombination-deficient tumors

Mechanisms of increased risk of tumorigenesis in Atm and Brca1 double heterozygosity

Ibuprofen prevents progression of ataxia telangiectasia symptoms in ATM-deficient mice

Gadd45a deletion aggravates hematopoietic stem cell dysfunction in ATM-deficient mice

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Combined inhibition of EZH2 and ATM is synthetic lethal in BRCA1-deficient breast cancer

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Other Objects (12)

Combination of EZH2 and ATM inhibition in BAP1-deficient mesothelioma

Drug combination studies of EZH2 inhibition combined with ATM, PI3-Kinase and CDK inhibitors in BRCA1-deficient breast tumors

BRCA1 deficient mammary tumors are dependent on EZH2 expression and sensitive to polycomp repressive complex 2-inhibitor 3-deazaneplanocin A

BRCA1-deficient mammary tumor cells are dependent on EZH2 expression and sensitive to Polycomb Repressive Complex 2-inhibitor 3-deazaneplanocin A

Inhibition of ATM kinase rescues planarian regeneration after lethal radiation

Funktionelle und mechanistische Charakterisierung von EZH2 in Atm-defizienten Subtypen des Pankreaskarzinoms

The biology and molecular vulnerabilities of ATM-deficient cancers

PARG deficiency is neither synthetic lethal with BRCA1 nor PTEN deficiency

Polθ: emerging synthetic lethal partner in homologous recombination-deficient tumors

Mechanisms of increased risk of tumorigenesis in Atm and Brca1 double heterozygosity

Ibuprofen prevents progression of ataxia telangiectasia symptoms in ATM-deficient mice

Gadd45a deletion aggravates hematopoietic stem cell dysfunction in ATM-deficient mice

Combination of EZH2 and ATM inhibition in BAP1-deficient mesothelioma

Drug combination studies of EZH2 inhibition combined with ATM, PI3-Kinase and CDK inhibitors in BRCA1-deficient breast tumors

BRCA1 deficient mammary tumors are dependent on EZH2 expression and sensitive to polycomp repressive complex 2-inhibitor 3-deazaneplanocin A

BRCA1-deficient mammary tumor cells are dependent on EZH2 expression and sensitive to Polycomb Repressive Complex 2-inhibitor 3-deazaneplanocin A

Inhibition of ATM kinase rescues planarian regeneration after lethal radiation

Funktionelle und mechanistische Charakterisierung von EZH2 in Atm-defizienten Subtypen des Pankreaskarzinoms

The biology and molecular vulnerabilities of ATM-deficient cancers

PARG deficiency is neither synthetic lethal with BRCA1 nor PTEN deficiency

Polθ: emerging synthetic lethal partner in homologous recombination-deficient tumors

Mechanisms of increased risk of tumorigenesis in Atm and Brca1 double heterozygosity

Ibuprofen prevents progression of ataxia telangiectasia symptoms in ATM-deficient mice

Gadd45a deletion aggravates hematopoietic stem cell dysfunction in ATM-deficient mice

Combination of EZH2 and ATM inhibition in BAP1-deficient mesothelioma

Drug combination studies of EZH2 inhibition combined with ATM, PI3-Kinase and CDK inhibitors in BRCA1-deficient breast tumors

BRCA1 deficient mammary tumors are dependent on EZH2 expression and sensitive to polycomp repressive complex 2-inhibitor 3-deazaneplanocin A

BRCA1-deficient mammary tumor cells are dependent on EZH2 expression and sensitive to Polycomb Repressive Complex 2-inhibitor 3-deazaneplanocin A

Inhibition of ATM kinase rescues planarian regeneration after lethal radiation

Funktionelle und mechanistische Charakterisierung von EZH2 in Atm-defizienten Subtypen des Pankreaskarzinoms

The biology and molecular vulnerabilities of ATM-deficient cancers

PARG deficiency is neither synthetic lethal with BRCA1 nor PTEN deficiency

Polθ: emerging synthetic lethal partner in homologous recombination-deficient tumors

Mechanisms of increased risk of tumorigenesis in Atm and Brca1 double heterozygosity

Ibuprofen prevents progression of ataxia telangiectasia symptoms in ATM-deficient mice

Gadd45a deletion aggravates hematopoietic stem cell dysfunction in ATM-deficient mice

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