Murine genotype impacts pancreatitis severity and systemic inflammation: an experimental study

Abstract: Background: Little is known regarding the impact of host response in acute pancreatitis. Here, we induce murine necrotizing pancreatitis in 9 different mouse strains.
Materials and methods: We examined 9 different mouse strains: Balb/CB4J, C3H/HEJ, NOD/SHILT, A/J, AKR/J, C57BI/6J, DBA/2J, FVB/NJ, 129S1/SvlmJ. 10 animals per strain were randomly allotted to two groups. Sterile necrotizing pancreatitis was induced by injection of taurocholate into the common bile duct. Control animals were injected with saline. Every 6 h, clinical parameters were examined and scored. After 24 h, animals were sacrificed to examine and compare serum enzymes, histology, bronchoalveolar lavage fluid, and serum IL-6.
Results: Histologically, taurocholate treated animals scored significantly higher than control animals. Concordantly, serum lipase and amylase were significantly elevated in pancreatitis animals in all strains. NOD/SHILT and AKR/J mice had the highest enzyme activity. 24 h after induction, there were no signs of increased pulmonary vascular leak in taurocholate animals. Remarkably, interleukin 6 was not increased at all in C57BL/6J, C3H/HeJ, and 129S1/SvlmJ mice compared to all other strains.
Conclusion: The genetic strain has an impact on pancreatitis severity and systemic inflammatory response in a murine taurocholate induction model. Analogous differences in humans may partially account for the disparity in post-ERCP pancreatitis

Angaben zum Objekt

• Standort: Deutsche Nationalbibliothek Frankfurt am Main
• Umfang: Online-Ressource
• Sprache: Englisch
• Anmerkungen: Annals of medicine and surgery. Volume 24 (2017), pp 8-14, DOI 10.1016/j.amsu.2017.09.012, issn: 2049-0801

Klassifikation und Themen

• Schlagwort: Bauchspeicheldrüse ; Bauchspeicheldrüsenentzündung ; Taurocholsäure ; Akute Bauchspeicheldrüsenentzündung

Beteiligte, Orts- und Zeitangaben

• Ereignis: Veröffentlichung
• (wo): Freiburg
• (wer): Universität
• (wann): 2018
• Urheber: Seifert, Gabriel ; Sander, Karoline ; Richter, Cornelia Sabine ; Wittel, Uwe Alexander
• Beteiligte Personen und Organisationen: Klinik für Allgemein- und Viszeralchirurgie. Freiburg im Breisgau ; Albert-Ludwigs-Universität Freiburg

Weitere Informationen

• DOI: 10.1016/j.amsu.2017.09.012
• URN: urn:nbn:de:bsz:25-freidok-146701
• Rechteinformation: Kein Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
• Letzte Aktualisierung: 25.03.2025, 13:47 MEZ