Human CD38 regulates B cell antigen receptor dynamic organization in normal and malignant B cells

Abstract: CD38 is a multifunctional protein expressed on the surface of B cells in healthy individuals but also in B cell malignancies. Previous studies have suggested a connection between CD38 and components of the IgM class B cell antigen receptor (IgM-BCR) and its coreceptor complex. Here, we provide evidence that CD38 is closely associated with CD19 in resting B cells and with the IgM-BCR upon engagement. We show that targeting CD38 with an antibody, or removing this molecule with CRISPR/Cas9, inhibits the association of CD19 with the IgM-BCR, impairing BCR signaling in normal and malignant B cells. Together, our data suggest that CD38 is a new member of the BCR coreceptor complex, where it exerts a modulatory effect on B cell activation upon antigen recognition by regulating CD19. Our study also reveals a new mechanism where α-CD38 antibodies could be a valuable option in therapeutic approaches to B cell malignancies driven by aberrant BCR signaling

Angaben zum Objekt

• Standort: Deutsche Nationalbibliothek Frankfurt am Main
• Umfang: Online-Ressource
• Sprache: Englisch
• Anmerkungen: ISSN: 1540-9538

Beteiligte, Orts- und Zeitangaben

• Ereignis: Veröffentlichung
• (wo): Freiburg
• (wer): Universität
• (wann): 2024
• Urheber: Camponeschi, Alessandro ; Kläsener, Anne Kathrin ; Sundell, Timothy ; Lundqvist, Christina ; Manna, Paul T. ; Ayoubzadeh, Negar ; Sundqvist, Martina ; Thorarinsdottir, Katrin ; Gatto, Mariele ; Visentini, Marcella ; Önnheim, Karin ; Aranburu, Alaitz ; Forsman, Huamei ; Ekwall, Olov ; Fogelstrand, Linda ; Gjertsson, Inger ; Reth, Michael ; Mårtensson, Inga-Lill

Weitere Informationen

• DOI: 10.1084/jem.20220201
• URN: urn:nbn:de:bsz:25-freidok-2451751
• Rechteinformation: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
• Letzte Aktualisierung: 25.03.2025, 13:56 MEZ