Identification of ZG16B as a prognostic biomarker in breast cancer
Abstract: Zymogen granule protein 16B (ZG16B) has been identified in various cancers, while so far the association between ZG16B and breast cancer hasn’t been explored. Our aim is to confirm whether it can serve as a prognostic biomarker in breast cancer. In this study, Oncomine, Cancer Cell Line Encyclopedia (CCLE), Ualcan, and STRING database analyses were conducted to detect the expression level of ZG16B in breast cancer with different types. Kaplan–Meier plotter was used to analyze the prognosis of patients with high or low expression of ZG16B. We found that ZG16B was significantly upregulated in breast cancer. Moreover, ZG16B was closely associated with foregone biomarkers and crucial factors in breast cancer. In the survival analysis, high expression of ZG16B represents a favorable prognosis in patients. Our work demonstrates the latent capacity of ZG16B to be a biomarker for prognosis of breast cancer.
- Standort
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Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
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Online-Ressource
- Sprache
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Englisch
- Erschienen in
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Identification of ZG16B as a prognostic biomarker in breast cancer ; volume:16 ; number:1 ; year:2020 ; pages:1-13 ; extent:13
Open medicine ; 16, Heft 1 (2020), 1-13 (gesamt 13)
- Urheber
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Lu, Haotian
Shi, Chunying
Liu, Xinyu
Liang, Chen
Yang, Chaochao
Wan, Xueqi
Li, Ling
Liu, Ying
- DOI
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10.1515/med-2021-0004
- URN
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urn:nbn:de:101:1-2022092014410629354238
- Rechteinformation
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
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15.08.2025, 07:39 MESZ
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Beteiligte
- Lu, Haotian
- Shi, Chunying
- Liu, Xinyu
- Liang, Chen
- Yang, Chaochao
- Wan, Xueqi
- Li, Ling
- Liu, Ying
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