Bioreactor design for the mechanical stimulation by compression of 3D cell cultures
Abstract: Bioreactors with a controlled physiological environment are being developed to study various cell processes. The influences of mechanostimulation on bone cell cultures can be investigated using a compression bioreactor. The developed bioreactor system applies a cyclic compression force to the specimen via an eccentrically mounted push rod. The compression force is monitored by a force sensor to detect changes in the material properties of the specimen. Depending on the piston setting, a stroke of 0.28 - 2.50 mm can be applied to the specimen. The bioreactor system was tested with a trial run of 18 days. A sample was continuously stimulated with a loading frequency of 2 Hz and a stroke of 1.50 mm. The sterility in the cell chamber as well as the functionality of the realised bioreactor stimulation system could be successfully confirmed
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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Bioreactor design for the mechanical stimulation by compression of 3D cell cultures ; volume:7 ; number:2 ; year:2021 ; pages:899-902 ; extent:4
Current directions in biomedical engineering ; 7, Heft 2 (2021), 899-902 (gesamt 4)
- Creator
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Micheler, Carina M.
Geck, Paulina A.
Charitou, Fiona
Leix, René
Foehr, Peter
Lang, Jan J.
Wilhelm, Nikolas J.
Tuebel, Jutta L.
Burgkart, Rainer H. H.
- DOI
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10.1515/cdbme-2021-2229
- URN
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urn:nbn:de:101:1-2022101214091900988414
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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15.08.2025, 7:26 AM CEST
Data provider
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Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Micheler, Carina M.
- Geck, Paulina A.
- Charitou, Fiona
- Leix, René
- Foehr, Peter
- Lang, Jan J.
- Wilhelm, Nikolas J.
- Tuebel, Jutta L.
- Burgkart, Rainer H. H.
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