Bioreactor design for the mechanical stimulation by compression of 3D cell cultures
Abstract: Bioreactors with a controlled physiological environment are being developed to study various cell processes. The influences of mechanostimulation on bone cell cultures can be investigated using a compression bioreactor. The developed bioreactor system applies a cyclic compression force to the specimen via an eccentrically mounted push rod. The compression force is monitored by a force sensor to detect changes in the material properties of the specimen. Depending on the piston setting, a stroke of 0.28 - 2.50 mm can be applied to the specimen. The bioreactor system was tested with a trial run of 18 days. A sample was continuously stimulated with a loading frequency of 2 Hz and a stroke of 1.50 mm. The sterility in the cell chamber as well as the functionality of the realised bioreactor stimulation system could be successfully confirmed
- Standort
-
Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
-
Online-Ressource
- Sprache
-
Englisch
- Erschienen in
-
Bioreactor design for the mechanical stimulation by compression of 3D cell cultures ; volume:7 ; number:2 ; year:2021 ; pages:899-902 ; extent:4
Current directions in biomedical engineering ; 7, Heft 2 (2021), 899-902 (gesamt 4)
- Urheber
-
Micheler, Carina M.
Geck, Paulina A.
Charitou, Fiona
Leix, René
Foehr, Peter
Lang, Jan J.
Wilhelm, Nikolas J.
Tuebel, Jutta L.
Burgkart, Rainer H. H.
- DOI
-
10.1515/cdbme-2021-2229
- URN
-
urn:nbn:de:101:1-2022101214091900988414
- Rechteinformation
-
Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
-
15.08.2025, 07:26 MESZ
Datenpartner
Dieses Objekt wird bereitgestellt von:
Deutsche Nationalbibliothek. Bei Fragen zum Objekt wenden Sie sich bitte an den Datenpartner.
Deutsche Nationalbibliothek. Bei Fragen zum Objekt wenden Sie sich bitte an den Datenpartner.
Beteiligte
- Micheler, Carina M.
- Geck, Paulina A.
- Charitou, Fiona
- Leix, René
- Foehr, Peter
- Lang, Jan J.
- Wilhelm, Nikolas J.
- Tuebel, Jutta L.
- Burgkart, Rainer H. H.
Ähnliche Objekte (12)
Design and Development of a Bioreactor System for Mechanical Stimulation of Musculoskeletal Tissue
Bioreactor for mobilization of mesenchymal stem/stromal cells into scaffolds under mechanical stimulation: Preliminary results
Optimizing artificial meniscus by mechanical stimulation of the chondrocyte-laden acellular meniscus using ad hoc bioreactor
Mechanical stimulation of mesenchymal stem/stromal cells in a bioreactor system: An approach to mobilize cells into scaffolds
Proteoglycan Breakdown of Meniscal Explants Following Dynamic Compression Using a Novel Bioreactor
Next generation bioreactor with cyclic mechanical stretch on biomimetic lung tissue
Mechanical deformation behavior of materials during compression
Mechanical compression in cofacial porphyrin cyclophane pincers
Induction of secondary metabolism of Aspergillus terreus ATCC 20542 in the batch bioreactor cultures
Temperature limited fed-batch technique for control of proteolysis in Pichia pastoris bioreactor cultures
Mechanical stimulation of bone healing
Electrical stimulation of NIH-3T3 cells with platinum-PEDOT-electrodes integrated in a bioreactor
Design and Development of a Bioreactor System for Mechanical Stimulation of Musculoskeletal Tissue
Bioreactor for mobilization of mesenchymal stem/stromal cells into scaffolds under mechanical stimulation: Preliminary results
Optimizing artificial meniscus by mechanical stimulation of the chondrocyte-laden acellular meniscus using ad hoc bioreactor
Mechanical stimulation of mesenchymal stem/stromal cells in a bioreactor system: An approach to mobilize cells into scaffolds
Proteoglycan Breakdown of Meniscal Explants Following Dynamic Compression Using a Novel Bioreactor
Next generation bioreactor with cyclic mechanical stretch on biomimetic lung tissue
Mechanical deformation behavior of materials during compression
Mechanical compression in cofacial porphyrin cyclophane pincers
Induction of secondary metabolism of Aspergillus terreus ATCC 20542 in the batch bioreactor cultures
Temperature limited fed-batch technique for control of proteolysis in Pichia pastoris bioreactor cultures
Mechanical stimulation of bone healing
Electrical stimulation of NIH-3T3 cells with platinum-PEDOT-electrodes integrated in a bioreactor
Design and Development of a Bioreactor System for Mechanical Stimulation of Musculoskeletal Tissue
Bioreactor for mobilization of mesenchymal stem/stromal cells into scaffolds under mechanical stimulation: Preliminary results
Optimizing artificial meniscus by mechanical stimulation of the chondrocyte-laden acellular meniscus using ad hoc bioreactor
Mechanical stimulation of mesenchymal stem/stromal cells in a bioreactor system: An approach to mobilize cells into scaffolds
Proteoglycan Breakdown of Meniscal Explants Following Dynamic Compression Using a Novel Bioreactor
Next generation bioreactor with cyclic mechanical stretch on biomimetic lung tissue
Mechanical deformation behavior of materials during compression
Mechanical compression in cofacial porphyrin cyclophane pincers
Induction of secondary metabolism of Aspergillus terreus ATCC 20542 in the batch bioreactor cultures
Temperature limited fed-batch technique for control of proteolysis in Pichia pastoris bioreactor cultures
Mechanical stimulation of bone healing