Targeting CD26/DPP4 in organ fibrosis
Abstract: CD26/DPP4 is an exopeptidase that is expressed as a transmembrane protein in many organs but also present in a circulating soluble form. Beyond its enzymatic and co-stimulatory activity, CD26/DPP4 is involved in the pathogenesis of chronic fibrotic diseases across many organ types, such as liver cirrhosis, kidney and lung fibrosis. Organ fibrosis is associated with a high morbidity and mortality and there are no causative therapies that can effectively attenuate the progress of the disease. Growing evidence suggests that inhibiting CD26/DPP4 can modulate the profibrotic tissue microenvironment and thus reduce fibrotic changes within affected organs.
This review summarizes the role of CD26/DPP4 in fibroproliferative disorders and highlights new opportunities for antifibrotic treatment by CD26/DPP4 inhibition. As a major advantage, CD26/DPP4 inhibitors are in safe and routine clinical use in type 2 diabetes for many years and thus qualify to repurpose them as a promising therapeutic against fibrosis
- Standort
-
Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
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Online-Ressource
- Sprache
-
Englisch
- Anmerkungen
-
British journal of pharmacology. - 180, 22 (2023) , 2846-2861, ISSN: 1476-5381
- Ereignis
-
Veröffentlichung
- (wo)
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Freiburg
- (wer)
-
Universität
- (wann)
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2022
- Urheber
- DOI
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10.1111/bph.15967
- URN
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urn:nbn:de:bsz:25-freidok-2302149
- Rechteinformation
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
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25.03.2025, 13:44 MEZ
Datenpartner
Deutsche Nationalbibliothek. Bei Fragen zum Objekt wenden Sie sich bitte an den Datenpartner.
Beteiligte
- Ohm, Birte
- Moneke, Isabelle
- Jungraithmayr, Wolfgang
- Universität
Entstanden
- 2022
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