Cerebral Amyloid Angiopathy with Lobar Haemorrhages and CAA-Related Inflammation in an Indian Family

zu Verbundenen Objekten

Introduction: Cerebral amyloid angiopathy (CAA) is a common cause of lobar intracerebral haemorrhage. Sporadic CAA is far more common than hereditary CAA (h-CAA). Familial CAA has not yet been described from India. Case Report: Two elderly Indian women (a mother and daughter) presented 7 years apart with features of CAA. The mother had presented with features of CAA-related inflammation that responded to steroids, whereas the daughter presented with features of CAA-related intracerebral haemorrhage. Clinical exome testing did not reveal any known genetic variants associated with h-CAA. Discussion: Although clinical exome testing was inconclusive, the presentation of CAA in two generations (mother and daughter) in their 8th and 7th decades, respectively, raises the possibility of a familial CAA rather than a sporadic CAA in this Indian family. Genome-wide association studies are necessary to reveal if an Indian variant of familial CAA exists. We compare and contrast our familial CAA with the described h-CAA variants in the literature.

Standort
Deutsche Nationalbibliothek Frankfurt am Main
Umfang
Online-Ressource
Sprache
Englisch

Erschienen in
Cerebral Amyloid Angiopathy with Lobar Haemorrhages and CAA-Related Inflammation in an Indian Family ; volume:12 ; number:1 ; year:2022 ; pages:23-27 ; extent:5
Cerebrovascular diseases / Extra. Extra ; 12, Heft 1 (2022), 23-27 (gesamt 5)

Urheber
Maramattom, Boby Varkey

DOI
10.1159/000522214
URN
urn:nbn:de:101:1-2022051200274947119277
Rechteinformation
Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
Letzte Aktualisierung
15.08.2025, 07:30 MESZ

Datenpartner

Dieses Objekt wird bereitgestellt von:
Deutsche Nationalbibliothek. Bei Fragen zum Objekt wenden Sie sich bitte an den Datenpartner.
Original beim Datenpartner anzeigen

Beteiligte

  • Maramattom, Boby Varkey

Ähnliche Objekte (12)

Differences in lobar microbleed topography in cerebral amyloid angiopathy and hypertensive arteriopathy

Differences in lobar microbleed topography in cerebral amyloid angiopathy and hypertensive arteriopathy

Cerebral amyloid angiopathy-related acute lobar intra-cerebral hemorrhage: diagnostic value of plain CT

Cerebral amyloid angiopathy-related acute lobar intra-cerebral hemorrhage: diagnostic value of plain CT

Cerebral amyloid angiopathy: an update

Cerebral amyloid angiopathy: an update

Evidence of amyloid-β cerebral amyloid angiopathy transmission through neurosurgery

Evidence of amyloid-β cerebral amyloid angiopathy transmission through neurosurgery

Cerebral hypoperfusion accelerates cerebral amyloid angiopathy and promotes cortical microinfarcts

Cerebral hypoperfusion accelerates cerebral amyloid angiopathy and promotes cortical microinfarcts

Probable cerebral amyloid angiopathy diagnosed on plain CT

Probable cerebral amyloid angiopathy diagnosed on plain CT

Probable cerebral amyloid angiopathy diagnosed on plain CT

Probable cerebral amyloid angiopathy diagnosed on plain CT

Intravenous injection of beta-amyloid seeds promotes cerebral amyloid angiopathy (CAA)

Intravenous injection of beta-amyloid seeds promotes cerebral amyloid angiopathy (CAA)

Reduced vascular amyloid burden at microhemorrhage sites in cerebral amyloid angiopathy

Reduced vascular amyloid burden at microhemorrhage sites in cerebral amyloid angiopathy

Retinal amyloid angiopathy

Retinal amyloid angiopathy

Multiple cerebral microinfarcts: an uncommon presentation of Cerebral Amyloid Angiopathy-related inflammation

Multiple cerebral microinfarcts: an uncommon presentation of Cerebral Amyloid Angiopathy-related inflammation

Peripartum Cerebral Angiopathy

Peripartum Cerebral Angiopathy

Verbundene Objekte