Cerebral Amyloid Angiopathy with Lobar Haemorrhages and CAA-Related Inflammation in an Indian Family
Introduction: Cerebral amyloid angiopathy (CAA) is a common cause of lobar intracerebral haemorrhage. Sporadic CAA is far more common than hereditary CAA (h-CAA). Familial CAA has not yet been described from India. Case Report: Two elderly Indian women (a mother and daughter) presented 7 years apart with features of CAA. The mother had presented with features of CAA-related inflammation that responded to steroids, whereas the daughter presented with features of CAA-related intracerebral haemorrhage. Clinical exome testing did not reveal any known genetic variants associated with h-CAA. Discussion: Although clinical exome testing was inconclusive, the presentation of CAA in two generations (mother and daughter) in their 8th and 7th decades, respectively, raises the possibility of a familial CAA rather than a sporadic CAA in this Indian family. Genome-wide association studies are necessary to reveal if an Indian variant of familial CAA exists. We compare and contrast our familial CAA with the described h-CAA variants in the literature.
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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Cerebral Amyloid Angiopathy with Lobar Haemorrhages and CAA-Related Inflammation in an Indian Family ; volume:12 ; number:1 ; year:2022 ; pages:23-27 ; extent:5
Cerebrovascular diseases / Extra. Extra ; 12, Heft 1 (2022), 23-27 (gesamt 5)
- Creator
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Maramattom, Boby Varkey
- DOI
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10.1159/000522214
- URN
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urn:nbn:de:101:1-2022051200274947119277
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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15.08.2025, 7:30 AM CEST
Data provider
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Maramattom, Boby Varkey
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Differences in lobar microbleed topography in cerebral amyloid angiopathy and hypertensive arteriopathy
Cerebral amyloid angiopathy-related acute lobar intra-cerebral hemorrhage: diagnostic value of plain CT
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Evidence of amyloid-β cerebral amyloid angiopathy transmission through neurosurgery
Cerebral hypoperfusion accelerates cerebral amyloid angiopathy and promotes cortical microinfarcts
Probable cerebral amyloid angiopathy diagnosed on plain CT
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Intravenous injection of beta-amyloid seeds promotes cerebral amyloid angiopathy (CAA)
Reduced vascular amyloid burden at microhemorrhage sites in cerebral amyloid angiopathy
Retinal amyloid angiopathy
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Differences in lobar microbleed topography in cerebral amyloid angiopathy and hypertensive arteriopathy
Cerebral amyloid angiopathy-related acute lobar intra-cerebral hemorrhage: diagnostic value of plain CT
Cerebral amyloid angiopathy: an update
Evidence of amyloid-β cerebral amyloid angiopathy transmission through neurosurgery
Cerebral hypoperfusion accelerates cerebral amyloid angiopathy and promotes cortical microinfarcts
Probable cerebral amyloid angiopathy diagnosed on plain CT
Probable cerebral amyloid angiopathy diagnosed on plain CT
Intravenous injection of beta-amyloid seeds promotes cerebral amyloid angiopathy (CAA)
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