Solvent Minimized Synthesis of Amides by Reactive Extrusion

zu Verbundenen Objekten

Abstract: Herein, we report on the translation of a small scale ball‐milled amidation protocol into a large scale continuous reactive extrusion process. Critical components to the successful translation were: a) understanding how the different operating parameters of a twin‐screw extruder should be harnessed to control prolonged continuous operation, and b) consideration of the physical form of the input materials. The amidation reaction is applied to 36 amides spanning a variety of physical form combinations (liquid‐liquid, solid–liquid and solid‐solid). Following this learning process, we have developed an understanding for the translation of each physical form combination and demonstrated a 7‐hour reactive extrusion process for the synthesis of an amide on 500 gram scale (1.3 mols of product).

Standort
Deutsche Nationalbibliothek Frankfurt am Main
Umfang
Online-Ressource
Sprache
Englisch

Erschienen in
Solvent Minimized Synthesis of Amides by Reactive Extrusion ; day:09 ; month:09 ; year:2024 ; extent:9
Angewandte Chemie / International edition. International edition ; (09.09.2024) (gesamt 9)

Urheber
Bolt, Robert R. A.
Smallman, Harry R.
Leitch, Jamie A.
Bluck, Gavin W.
Barreteau, Fabien
Iosub, Andrei V.
Constable, David
Dapremont, Olivier
Richardson, Paul
Browne, Duncan L.

DOI
10.1002/anie.202408315
URN
urn:nbn:de:101:1-2409101409575.710041493986
Rechteinformation
Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
Letzte Aktualisierung
15.08.2025, 07:35 MESZ

Datenpartner

Dieses Objekt wird bereitgestellt von:
Deutsche Nationalbibliothek. Bei Fragen zum Objekt wenden Sie sich bitte an den Datenpartner.
Original beim Datenpartner anzeigen

Beteiligte

  • Bolt, Robert R. A.
  • Smallman, Harry R.
  • Leitch, Jamie A.
  • Bluck, Gavin W.
  • Barreteau, Fabien
  • Iosub, Andrei V.
  • Constable, David
  • Dapremont, Olivier
  • Richardson, Paul
  • Browne, Duncan L.

Ähnliche Objekte (12)

Solvent Minimized Synthesis of Amides by Reactive Extrusion

Solvent Minimized Synthesis of Amides by Reactive Extrusion

Reactive extrusion : principles and applications

Reactive extrusion : principles and applications

Scale-up of solvent-free, mechanochemical precursor synthesis for nanoporous carbon materials via extrusion

Scale-up of solvent-free, mechanochemical precursor synthesis for nanoporous carbon materials via extrusion

Scale‐Up of Solvent‐Free, Mechanochemical Precursor Synthesis for Nanoporous Carbon Materials via Extrusion

Scale‐Up of Solvent‐Free, Mechanochemical Precursor Synthesis for Nanoporous Carbon Materials via Extrusion

Extrusion of Isocyanate from N-Allyl Amides Enables π-Allyl Palladium Chemistry!

Extrusion of Isocyanate from N-Allyl Amides Enables π-Allyl Palladium Chemistry!

Metal- and solvent-free synthesis of amides using substitute formamides as an amino source under mild conditions

Metal- and solvent-free synthesis of amides using substitute formamides as an amino source under mild conditions

Reactive extrusion : principles and practice ; a monograph

Reactive extrusion : principles and practice ; a monograph

Synthesis of functionalised β-keto amides by aminoacylation/domino fragmentation of β-enamino amides

Synthesis of functionalised β-keto amides by aminoacylation/domino fragmentation of β-enamino amides

MICROWAVE-PROMOTED CONVERSION OF HETEROCYCLIC AMINES TO CORRESPONDING AMIDES UNDER SOLVENT-FREE CONDITIONS

MICROWAVE-PROMOTED CONVERSION OF HETEROCYCLIC AMINES TO CORRESPONDING AMIDES UNDER SOLVENT-FREE CONDITIONS

Synthesis of tailor-made bicyclic [4.3.1] aza-amides

Synthesis of tailor-made bicyclic [4.3.1] aza-amides

Solvent-free organic synthesis

Praktikum

Solvent-free organic synthesis

Solvent-free organic synthesis

Praktikum

Solvent-free organic synthesis

Verbundene Objekte