Solvent Minimized Synthesis of Amides by Reactive Extrusion

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Abstract: Herein, we report on the translation of a small scale ball‐milled amidation protocol into a large scale continuous reactive extrusion process. Critical components to the successful translation were: a) understanding how the different operating parameters of a twin‐screw extruder should be harnessed to control prolonged continuous operation, and b) consideration of the physical form of the input materials. The amidation reaction is applied to 36 amides spanning a variety of physical form combinations (liquid‐liquid, solid–liquid and solid‐solid). Following this learning process, we have developed an understanding for the translation of each physical form combination and demonstrated a 7‐hour reactive extrusion process for the synthesis of an amide on 500 gram scale (1.3 mols of product).

Location: Deutsche Nationalbibliothek Frankfurt am Main

Extent: Online-Ressource

Language: Englisch

Bibliographic citation: Solvent Minimized Synthesis of Amides by Reactive Extrusion ; day:09 ; month:09 ; year:2024 ; extent:9
Angewandte Chemie ; (09.09.2024) (gesamt 9)

Creator: Bolt, Robert R. A.
Smallman, Harry R.
Leitch, Jamie A.
Bluck, Gavin W.
Barreteau, Fabien
Iosub, Andrei V.
Constable, David
Dapremont, Olivier
Richardson, Paul
Browne, Duncan L.

DOI: 10.1002/ange.202408315

URN: urn:nbn:de:101:1-2409101410533.891594274615

Rights: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.

Last update: 15.08.2025, 7:24 AM CEST

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Bolt, Robert R. A.
Smallman, Harry R.
Leitch, Jamie A.
Bluck, Gavin W.
Barreteau, Fabien
Iosub, Andrei V.
Constable, David
Dapremont, Olivier
Richardson, Paul
Browne, Duncan L.

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Solvent Minimized Synthesis of Amides by Reactive Extrusion

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