Fluorescent light energy modulates healing in skin grafted mouse model
Abstract: Skin grafting is often the only treatment for skin trauma when large areas of tissue are affected. This surgical intervention damages the deeper dermal layers of the skin with implications for wound healing and a risk of scar development. Photobiomodulation (PBM) therapy modulates biological processes in different tissues, with a positive effect on many cell types and pathways essential for wound healing. This study investigated the effect of fluorescent light energy (FLE) therapy, a novel type of PBM, on healing after skin grafting in a dermal fibrotic mouse model. Split-thickness human skin grafts were transplanted onto full-thickness excisional wounds on nude mice. Treated wounds were monitored, and excised xenografts were examined to assess healing and pathophysiological processes essential for developing chronic wounds or scarring. Results demonstrated that FLE treatment initially accelerated re-epithelialization and rete ridge formation, while later reduced neovascularization, collagen deposition, myofibroblast and mast cell accumulation, and connective tissue growth factor expression. While there was no visible difference in gross morphology, we found that FLE treatment promoted a balanced collagen remodeling. Collectively, these findings suggest that FLE has a conceivable effect at balancing healing after skin grafting, which reduces the risk of infections, chronic wound development, and fibrotic scarring.
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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Fluorescent light energy modulates healing in skin grafted mouse model ; volume:16 ; number:1 ; year:2021 ; pages:1240-1255 ; extent:16
Open medicine ; 16, Heft 1 (2021), 1240-1255 (gesamt 16)
- Creator
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Ding, Jie
Mellergaard, Maiken
Zhu, Zhensen
Kwan, Peter
Edge, Deirdre
Ma, Zengshuan
Hebert, Lise
Alrobaiea, Saad
Iwasaki, Takashi
Nielsen, Michael Canova Engelbrecht
Tredget, Edward E.
- DOI
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10.1515/med-2021-0329
- URN
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urn:nbn:de:101:1-2022092014133231579325
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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15.08.2025, 7:35 AM CEST
Data provider
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Ding, Jie
- Mellergaard, Maiken
- Zhu, Zhensen
- Kwan, Peter
- Edge, Deirdre
- Ma, Zengshuan
- Hebert, Lise
- Alrobaiea, Saad
- Iwasaki, Takashi
- Nielsen, Michael Canova Engelbrecht
- Tredget, Edward E.
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