Restricted access: spatial sequestration of damaged proteins during stress and aging

Abstract: The accumulation of damaged and aggregated proteins is a hallmark of aging and increased proteotoxic stress. To limit the toxicity of damaged and aggregated proteins and to ensure that the damage is not inherited by succeeding cell generations, a system of spatial quality control operates to sequester damaged/aggregated proteins into inclusions at specific protective sites. Such spatial sequestration and asymmetric segregation of damaged proteins have emerged as key processes required for cellular rejuvenation. In this review, we summarize findings on the nature of the different quality control sites identified in yeast, on genetic determinants required for spatial quality control, and on how aggregates are recognized depending on the stress generating them. We also briefly compare the yeast system to spatial quality control in other organisms. The data accumulated demonstrate that spatial quality control involves factors beyond the canonical quality control factors, such as chaperones and proteases, and opens up new venues in approaching how proteotoxicity might be mitigated, or delayed, upon aging.

Object Details

• Location: Deutsche Nationalbibliothek Frankfurt am Main
• Extent: Online-Ressource
• Language: Englisch

References and Relationships

• Bibliographic citation: Restricted access: spatial sequestration of damaged proteins during stress and aging ; volume:18 ; number:3 ; year:2017 ; pages:377-391 ; extent:15 ; EMBO reports / European Molecular Biology Organization ; 18, Heft 3 (2017), 377-391 (gesamt 15)

Contributors, Places and Time

• Creator: Hill, Sandra Malmgren ; Hanzén, Sarah ; Nyström, Thomas

Further information

• DOI: 10.15252/embr.201643458
• URN: urn:nbn:de:101:1-2022100906211695212516
• Rights: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
• Last update: 15.08.2025, 7:27 AM CEST