Global profiling of protein lactylation in Caenorhabditis elegans
Abstract: Lactylation, as a novel posttranslational modification, is essential for studying the functions and regulation of proteins in physiological and pathological processes, as well as for gaining in‐depth knowledge on the occurrence and development of many diseases, including tumors. However, few studies have examined the protein lactylation of one whole organism. Thus, we studied the lactylation of global proteins in Caenorhabditis elegans to obtain an in vivo lactylome. Using an MS‐based platform, we identified 1836 Class I (localization probabilities > 0.75) lactylated sites in 487 proteins. Bioinformatics analysis showed that lactylated proteins were mainly located in the cytoplasm and involved in the tricarboxylic acid cycle (TCA cycle) and other metabolic pathways. Then, we evaluated the conservation of lactylation in different organisms. In total, 41 C. elegans proteins were lactylated and homologous to lactylated proteins in humans and rats. Moreover, lactylation on H4K80 was conserved in three species. An additional 238 lactylated proteins were identified in C. elegans for the first time. This study establishes the first lactylome database in C. elegans and provides a basis for studying the role of lactylation.
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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Global profiling of protein lactylation in Caenorhabditis elegans ; day:17 ; month:10 ; year:2023 ; extent:9
Proteomics ; (17.10.2023) (gesamt 9)
- Creator
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Ding, Tao
Yang, Ye‐Hong
Wang, Qiao‐Chu
Wu, Yue
Han, Rong
Zhang, Xu‐Tong
Kong, Jie
Yang, Jun‐Tao
Liu, Jiang‐Feng
- DOI
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10.1002/pmic.202300185
- URN
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urn:nbn:de:101:1-2023101815040767485975
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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14.08.2025, 10:56 AM CEST
Data provider
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Ding, Tao
- Yang, Ye‐Hong
- Wang, Qiao‐Chu
- Wu, Yue
- Han, Rong
- Zhang, Xu‐Tong
- Kong, Jie
- Yang, Jun‐Tao
- Liu, Jiang‐Feng
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