Recent Applications of Mesoporous Silica Nanoparticles in Gene Therapy

Abstract: Gene therapy offers transformative potential for treating genetic disorders by directly addressing the molecular root causes of diseases. However, the primary challenges of gene therapy involve the efficient delivery of therapeutic genetic material to target cells, crossing biological barriers, managing toxicity and immune responses. Mesoporous silica nanoparticles (MSNs), due to their unique structural features have emerged as a promising platform to overcome these challenges. In recent years, MSNs have gained significant attention as potential nanocarriers for the efficient delivery of various nucleic acids. This review comprehensively examines the role of MSNs in gene therapy, focusing on their capabilities in the targeted delivery of siRNA, DNA, CRISPR‐Cas systems, and other genetic therapeutics. This work explores the modern advancements in MSNs synthesis and functionalization strategies and the impact of structural modifications on their stability, cellular uptake, and controlled release under physiological conditions. Additionally, the review highlights the use of MSNs to develop theranostic systems, where gene delivery is combined with diagnostic imaging for real‐time monitoring and personalized treatment strategies. Finally, this work discusses the future perspectives of MSNs in gene delivery, addressing regulatory challenges, enhancing clinical translation, and expanding their application for treating various genetic disorders and cancers.

Location
Deutsche Nationalbibliothek Frankfurt am Main
Extent
Online-Ressource
Language
Englisch

Bibliographic citation
Recent Applications of Mesoporous Silica Nanoparticles in Gene Therapy ; day:10 ; month:02 ; year:2025 ; extent:23
Advanced healthcare materials ; (10.02.2025) (gesamt 23)

Creator
Huq, Tamanna Binte
Anil Kumar Jeeja, Punnya
Dam, Sudip Kumar
Das, Sabya Sachi
Vivero‐Escoto, Juan L.

DOI
10.1002/adhm.202404781
URN
urn:nbn:de:101:1-2502111319394.245789862897
Rights
Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
Last update
15.08.2025, 7:35 AM CEST

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Associated

  • Huq, Tamanna Binte
  • Anil Kumar Jeeja, Punnya
  • Dam, Sudip Kumar
  • Das, Sabya Sachi
  • Vivero‐Escoto, Juan L.

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