Remotely Temporal Scheduled Macrophage Phenotypic Transition Enables Optimized Immunomodulatory Bone Regeneration
Abstract: Precise timing of macrophage polarization plays a pivotal role in immunomodulation of tissue regeneration, yet most studies mainly focus on M2 macrophages for their anti‐inflammatory and regenerative effects while the essential proinflammatory role of the M1 phenotype on the early inflammation stage is largely underestimated. Herein, a superparamagnetic hydrogel capable of timely controlling macrophage polarization is constructed by grafting superparamagnetic nanoparticles on collagen nanofibers. The magnetic responsive hydrogel network enables efficient polarization of encapsulated macrophage to the M2 phenotype through the podosome/Rho/ROCK mechanical pathway in response to static magnetic field (MF) as needed. Taking advantage of remote accessibility of magnetic field together with the superparamagnetic hydrogels, a temporal engineered M1 to M2 transition course preserving the essential role of M1 at the early stage of tissue healing, as well as enhancing the prohealing effect of M2 at the middle/late stages is established via delayed MF switch. Such precise timing of macrophage polarization matching the regenerative process of injured tissue eventually leads to optimized immunomodulatory bone healing in vivo. Overall, this study offers a remotely time‐scheduled approach for macrophage polarization, which enables precise manipulation of inflammation progression during tissue healing.
- Standort
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Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
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Online-Ressource
- Sprache
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Englisch
- Erschienen in
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Remotely Temporal Scheduled Macrophage Phenotypic Transition Enables Optimized Immunomodulatory Bone Regeneration ; day:28 ; month:08 ; year:2022 ; extent:20
Small ; (28.08.2022) (gesamt 20)
- Urheber
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Huang, Donghua
Xu, Kaicheng
Huang, Xin
Lin, Nong
Ye, Yuxiao
Lin, Suya
Zhang, Jiamin
Shao, Jiaqi
Chen, Songfeng
Shi, Mingmin
Zhou, Xingzhi
Lin, Peng
Xue, Yucheng
Yu, Chengcheng
Yu, Xiaohua
Ye, Zhaoming
Cheng, Kui
- DOI
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10.1002/smll.202203680
- URN
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urn:nbn:de:101:1-2022083015320190823060
- Rechteinformation
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
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15.08.2025, 07:20 MESZ
Datenpartner
Deutsche Nationalbibliothek. Bei Fragen zum Objekt wenden Sie sich bitte an den Datenpartner.
Beteiligte
- Huang, Donghua
- Xu, Kaicheng
- Huang, Xin
- Lin, Nong
- Ye, Yuxiao
- Lin, Suya
- Zhang, Jiamin
- Shao, Jiaqi
- Chen, Songfeng
- Shi, Mingmin
- Zhou, Xingzhi
- Lin, Peng
- Xue, Yucheng
- Yu, Chengcheng
- Yu, Xiaohua
- Ye, Zhaoming
- Cheng, Kui
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