Reducing mutant Huntingtin protein expression in living cells by a newly identified RNA CAG binder

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Location: Deutsche Nationalbibliothek Frankfurt am Main

Extent: Online-Ressource

Language: Englisch

Bibliographic citation: In: ACS Chemical Neuroscience, 9, 6, S. 1399-1408

Event: Veröffentlichung

(where): Augsburg

(who): Universität Augsburg

(when): 2018

Event: Veröffentlichung

(who): American Chemical Society (ACS)

(when): 2018

Creator: Matthes, Frank
Massari, Serena
Bochicchio, Anna
Schorpp, Kenji
Schilling, Judith
Weber, Stephanie
Offermann, Nina
Desantis, Jenny
Wanker, Erich
Carloni, Paolo
Hadian, Kamyar
Tabarrini, Oriana
Rossetti, Giulia
Krauss, Sybille

DOI: 10.1021/acschemneuro.8b00027

URN: urn:nbn:de:bvb:384-opus4-1094356

Rights: Der Zugriff auf das Objekt ist unbeschränkt möglich.

Last update: 15.08.2025, 7:33 AM CEST

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Associated

Matthes, Frank
Massari, Serena
Bochicchio, Anna
Schorpp, Kenji
Schilling, Judith
Weber, Stephanie
Offermann, Nina
Desantis, Jenny
Wanker, Erich
Carloni, Paolo
Hadian, Kamyar
Tabarrini, Oriana
Rossetti, Giulia
Krauss, Sybille
Universität Augsburg
American Chemical Society (ACS)

Time of origin

2018

Other Objects (12)

Cell-type-specific CAG repeat expansions and toxicity of mutant Huntingtin in human striatum and cerebellum

Attenuated huntingtin gene CAG nucleotide repeat size in individuals with Lynch syndrome

Dynamic recruitment of ubiquitin to mutant huntingtin inclusion bodies

Quantifying mutant huntingtin protein in human cerebrospinal fluid to support the development of huntingtin-lowering therapies

Truncation of mutant huntingtin in knock-in mice demonstrates exon1 huntingtin is a key pathogenic form

Huntingtin HTT1a is generated in a CAG repeat-length-dependent manner in human tissues

A Specific Mini‐Intrabody Mediates Lysosome Degradation of Mutant Huntingtin

Human-to-mouse prion-like propagation of mutant huntingtin protein

Mutant Huntingtin toxicity modifiers revealed by a spatiotemporal proteomic profiling

Comparative Analysis of Mutant Huntingtin Binding Partners in Yeast Species

Correction: Huntingtin HTT1a is generated in a CAG repeat-length-dependent manner in human tissues

Author Correction: Truncation of mutant huntingtin in knock-in mice demonstrates exon1 huntingtin is a key pathogenic form

Cell-type-specific CAG repeat expansions and toxicity of mutant Huntingtin in human striatum and cerebellum

Attenuated huntingtin gene CAG nucleotide repeat size in individuals with Lynch syndrome

Dynamic recruitment of ubiquitin to mutant huntingtin inclusion bodies

Quantifying mutant huntingtin protein in human cerebrospinal fluid to support the development of huntingtin-lowering therapies

Truncation of mutant huntingtin in knock-in mice demonstrates exon1 huntingtin is a key pathogenic form

Huntingtin HTT1a is generated in a CAG repeat-length-dependent manner in human tissues

A Specific Mini‐Intrabody Mediates Lysosome Degradation of Mutant Huntingtin

Human-to-mouse prion-like propagation of mutant huntingtin protein

Mutant Huntingtin toxicity modifiers revealed by a spatiotemporal proteomic profiling

Comparative Analysis of Mutant Huntingtin Binding Partners in Yeast Species

Correction: Huntingtin HTT1a is generated in a CAG repeat-length-dependent manner in human tissues

Author Correction: Truncation of mutant huntingtin in knock-in mice demonstrates exon1 huntingtin is a key pathogenic form

Cell-type-specific CAG repeat expansions and toxicity of mutant Huntingtin in human striatum and cerebellum

Attenuated huntingtin gene CAG nucleotide repeat size in individuals with Lynch syndrome

Dynamic recruitment of ubiquitin to mutant huntingtin inclusion bodies

Quantifying mutant huntingtin protein in human cerebrospinal fluid to support the development of huntingtin-lowering therapies

Truncation of mutant huntingtin in knock-in mice demonstrates exon1 huntingtin is a key pathogenic form

Huntingtin HTT1a is generated in a CAG repeat-length-dependent manner in human tissues

A Specific Mini‐Intrabody Mediates Lysosome Degradation of Mutant Huntingtin

Human-to-mouse prion-like propagation of mutant huntingtin protein

Mutant Huntingtin toxicity modifiers revealed by a spatiotemporal proteomic profiling

Comparative Analysis of Mutant Huntingtin Binding Partners in Yeast Species

Correction: Huntingtin HTT1a is generated in a CAG repeat-length-dependent manner in human tissues

Author Correction: Truncation of mutant huntingtin in knock-in mice demonstrates exon1 huntingtin is a key pathogenic form

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Reducing mutant Huntingtin protein expression in living cells by a newly identified RNA CAG binder

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Other Objects (12)

Cell-type-specific CAG repeat expansions and toxicity of mutant Huntingtin in human striatum and cerebellum

Attenuated huntingtin gene CAG nucleotide repeat size in individuals with Lynch syndrome

Dynamic recruitment of ubiquitin to mutant huntingtin inclusion bodies

Quantifying mutant huntingtin protein in human cerebrospinal fluid to support the development of huntingtin-lowering therapies

Truncation of mutant huntingtin in knock-in mice demonstrates exon1 huntingtin is a key pathogenic form

Huntingtin HTT1a is generated in a CAG repeat-length-dependent manner in human tissues

A Specific Mini‐Intrabody Mediates Lysosome Degradation of Mutant Huntingtin

Human-to-mouse prion-like propagation of mutant huntingtin protein

Mutant Huntingtin toxicity modifiers revealed by a spatiotemporal proteomic profiling

Comparative Analysis of Mutant Huntingtin Binding Partners in Yeast Species

Correction: Huntingtin HTT1a is generated in a CAG repeat-length-dependent manner in human tissues

Author Correction: Truncation of mutant huntingtin in knock-in mice demonstrates exon1 huntingtin is a key pathogenic form

Cell-type-specific CAG repeat expansions and toxicity of mutant Huntingtin in human striatum and cerebellum

Attenuated huntingtin gene CAG nucleotide repeat size in individuals with Lynch syndrome

Dynamic recruitment of ubiquitin to mutant huntingtin inclusion bodies

Quantifying mutant huntingtin protein in human cerebrospinal fluid to support the development of huntingtin-lowering therapies

Truncation of mutant huntingtin in knock-in mice demonstrates exon1 huntingtin is a key pathogenic form

Huntingtin HTT1a is generated in a CAG repeat-length-dependent manner in human tissues

A Specific Mini‐Intrabody Mediates Lysosome Degradation of Mutant Huntingtin

Human-to-mouse prion-like propagation of mutant huntingtin protein

Mutant Huntingtin toxicity modifiers revealed by a spatiotemporal proteomic profiling

Comparative Analysis of Mutant Huntingtin Binding Partners in Yeast Species

Correction: Huntingtin HTT1a is generated in a CAG repeat-length-dependent manner in human tissues

Author Correction: Truncation of mutant huntingtin in knock-in mice demonstrates exon1 huntingtin is a key pathogenic form

Cell-type-specific CAG repeat expansions and toxicity of mutant Huntingtin in human striatum and cerebellum

Attenuated huntingtin gene CAG nucleotide repeat size in individuals with Lynch syndrome

Dynamic recruitment of ubiquitin to mutant huntingtin inclusion bodies

Quantifying mutant huntingtin protein in human cerebrospinal fluid to support the development of huntingtin-lowering therapies

Truncation of mutant huntingtin in knock-in mice demonstrates exon1 huntingtin is a key pathogenic form

Huntingtin HTT1a is generated in a CAG repeat-length-dependent manner in human tissues

A Specific Mini‐Intrabody Mediates Lysosome Degradation of Mutant Huntingtin

Human-to-mouse prion-like propagation of mutant huntingtin protein

Mutant Huntingtin toxicity modifiers revealed by a spatiotemporal proteomic profiling

Comparative Analysis of Mutant Huntingtin Binding Partners in Yeast Species

Correction: Huntingtin HTT1a is generated in a CAG repeat-length-dependent manner in human tissues

Author Correction: Truncation of mutant huntingtin in knock-in mice demonstrates exon1 huntingtin is a key pathogenic form

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