TLRs1-10 Protein Expression in Circulating Human White Blood Cells during Bacterial and COVID-19 Infections

Toll-like receptors (TLRs) play a crucial role in severe infections. Overexpression of certain TLRs on neutrophils has been associated with increased mortality in patients with infection-induced shock, although the role of TLR4 overexpression is still debated. In addition, TLR7 and TLR8 recognize the SARS-CoV-2 virus, while the spike protein activates TLR4. In this study, we conducted a comprehensive analysis of TLR expression in white blood cells from patients with bacterial and viral infections. 71 patients were included, divided into 4 groups based on infection severity (sepsis, septic shock, moderate, and severe COVID-19), along with 7 control subjects. Notably, we observed a significant reduction in the expression of TLR4 and its co-receptor CD14 in neutrophils of patients with shock compared to controls. Furthermore, severe COVID-19 patients exhibited a significant increase in TLR3 and TLR7 levels in neutrophils compared to the control group. Patients with shock also showed a similar increase in TLR7 expression in neutrophils, along with elevated intermediate monocytes compared to controls. However, TLR expression remained unchanged in lymphocytes. This study provided further insights into the mechanisms of TLR activation in various severe forms of infection. Additional analysis is required to assess their correlation with patient outcomes and evaluate the potential impact of TLR-related therapy on neutrophil activation.

Object Details

• Location: Deutsche Nationalbibliothek Frankfurt am Main
• Extent: Online-Ressource
• Language: Englisch

References and Relationships

• Bibliographic citation: TLRs1-10 Protein Expression in Circulating Human White Blood Cells during Bacterial and COVID-19 Infections ; volume:16 ; number:1 ; year:2024 ; pages:216-225 ; extent:10 ; Journal of innate immunity ; 16, Heft 1 (2024), 216-225 (gesamt 10)

Contributors, Places and Time

• Creator: Chomel, Louise ; Vogt, Mathieu ; Demiselle, Julien ; Le Borgne, Pierrick ; Tschirhart, Marine ; Morandeau, Valentin ; Merdji, Hamid ; Miguet, Laurent ; Helms, Julie ; Meziani, Ferhat ; Mauvieux, Laurent

Further information

• DOI: 10.1159/000536593
• URN: urn:nbn:de:101:1-2406060118007.880699240237
• Rights: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
• Last update: 14.08.2025, 10:56 AM CEST