A Dunnett-Type Procedure for Multiple Endpoints
This paper describes a method for comparisons of several treatments with a control, simultaneously for multiple endpoints. These endpoints are assumed to be normally distributed with different scales and variances. An approximate multivariate t-distribution is used to obtain quantiles for test decisions, multiplicity-adjusted p-values, and simultaneous confidence intervals. Simulation results show that this approach controls the family-wise error type I over both the comparisons and the endpoints in an admissible range. The approach will be applied to a randomized clinical trial comparing two new sets of extracorporeal circulations with a standard for three primary endpoints. A related R package is available.
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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A Dunnett-Type Procedure for Multiple Endpoints ; volume:7 ; number:1 ; year:2011
The international journal of biostatistics ; 7, Heft 1 (2011)
- Creator
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Hasler, Mario
Hothorn, Ludwig A.
- DOI
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10.2202/1557-4679.1258
- URN
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urn:nbn:de:101:1-2502190349463.662609014449
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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15.08.2025, 7:31 AM CEST
Data provider
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Hasler, Mario
- Hothorn, Ludwig A.
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