Hearing loss and brain disorders: A review of multiple pathologies

Abstract: Several causative factors are associated with hearing loss (HL) and brain disorders. However, there are many unidentified disease modifiers in these conditions. Our study summarised the most common brain disorders associated with HL and highlighted mechanisms of pathologies. We searched the literature for published articles on HL and brain disorders. Alzheimer’s disease/dementia, Parkinson’s disease, cognitive impairment, autism spectrum disorder, ataxia, epilepsy, stroke, and hypoxic-ischaemic encephalopathy majorly co-interact with HL. The estimated incidence rate was 113 per 10,000 person-years. Genetic, epigenetic, early life/neonatal stress, hypoxia, inflammation, nitric oxide infiltration, endoplasmic reticulum stress, and excess glutamate were the distinguished modifiers identified. Various mechanisms like adhesion molecules, transport proteins, hair cell apoptosis, and neurodegeneration have been implicated in these conditions and are serving as potential targets for therapies. To improve the quality of life of patients, these understandings will improve clinical diagnoses and management of HL and brain disorders.

Object Details

• Location: Deutsche Nationalbibliothek Frankfurt am Main
• Extent: Online-Ressource
• Language: Englisch

References and Relationships

• Bibliographic citation: Hearing loss and brain disorders: A review of multiple pathologies ; volume:17 ; number:1 ; year:2021 ; pages:61-69 ; extent:9 ; Open medicine ; 17, Heft 1 (2021), 61-69 (gesamt 9)

Contributors, Places and Time

• Creator: Oluwole, Oluwafemi Gabriel ; James, Kili ; Yalcouye, Abdoulaye ; Wonkam, Ambroise

Further information

• DOI: 10.1515/med-2021-0402
• URN: urn:nbn:de:101:1-2022071516174071923302
• Rights: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
• Last update: 15.08.2025, 7:27 AM CEST