A New Mechanism for Hydroxyl Radical Production in Irradiated Nanoparticle Solutions
The absolute yield of hydroxyl radicals per unit of deposited X‐ray energy is determined for the first time for irradiated aqueous solutions containing metal nanoparticles based on a “reference” protocol. Measurements are made as a function of dose rate and nanoparticle concentration. Possible mechanisms for hydroxyl radical production are considered in turn: energy deposition in the nanoparticles followed by its transport into the surrounding environment is unable to account for observed yield whereas energy deposition in the water followed by a catalytic‐like reaction at the water‐nanoparticle interface can account for the total yield and its dependence on dose rate and nanoparticle concentration. This finding is important because current models used to account for nanoparticle enhancement to radiobiological damage only consider the primary interaction with the nanoparticle, not with the surrounding media. Nothing about the new mechanism appears to be specific to gold, the main requirements being the formation of a structured water layer in the vicinity of the nanoparticle possibly through the interaction of its charge and the water dipoles. The massive hydroxyl radical production is relevant to a number of application fields, particularly nanomedicine since the hydroxyl radical is responsible for the majority of radiation‐induced DNA damage.
- Location
-
Deutsche Nationalbibliothek Frankfurt am Main
- Extent
-
Online-Ressource
- Language
-
Englisch
- Bibliographic citation
-
A New Mechanism for Hydroxyl Radical Production in Irradiated Nanoparticle Solutions ; volume:10 ; number:16 ; year:2014 ; pages:3338-3346 ; extent:9
Small ; 10, Heft 16 (2014), 3338-3346 (gesamt 9)
- Creator
-
Sicard‐Roselli, Cécile
Brun, Emilie
Gilles, Manon
Baldacchino, Gérard
Kelsey, Colin
McQuaid, Harold
Polin, Chris
Wardlow, Nathan
Currell, Frederick
- DOI
-
10.1002/smll.201400110
- URN
-
urn:nbn:de:101:1-2023011606262895294565
- Rights
-
Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
-
15.08.2025, 7:28 AM CEST
Data provider
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Sicard‐Roselli, Cécile
- Brun, Emilie
- Gilles, Manon
- Baldacchino, Gérard
- Kelsey, Colin
- McQuaid, Harold
- Polin, Chris
- Wardlow, Nathan
- Currell, Frederick
Other Objects (12)
Phenylalanine as a hydroxyl radical-specific probe in pyrite slurries
Accurate protein structure prediction with hydroxyl radical protein footprinting data
Pyrite-induced hydroxyl radical formation and its effect on nucleic acids
Recent Advances in Detection of Hydroxyl Radical by Responsive Fluorescence Nanoprobes
The pro-radical hydrogen peroxide as a stable hydroxyl radical distributor: lessons from pancreatic beta cells
Capture and Stabilization of the Hydroxyl Radical in a Uranyl Peroxide Cluster **
Instantaneous monitoring of hydroxyl radical-mediated protein alterations by green fluorescent protein
Estimation of the atmospheric hydroxyl radical oxidative capacity using multiple hydrofluorocarbons (HFCs)
Secondary organic aerosol formation from hydroxyl radical oxidation and ozonolysis of monoterpenes
The kinetics and mechanism of an aqueous phase isoprene reaction with hydroxyl radical
Catalytically Active Ti‐Based Nanomaterials for Hydroxyl Radical Mediated Clinical X‐Ray Enhancement
Comparison of Hydroxyl Radical, Peroxyl Radical, and Peroxynitrite Scavenging Capacity of Extracts and Active Components from Selected Medicinal Plants
Phenylalanine as a hydroxyl radical-specific probe in pyrite slurries
Accurate protein structure prediction with hydroxyl radical protein footprinting data
Pyrite-induced hydroxyl radical formation and its effect on nucleic acids
Recent Advances in Detection of Hydroxyl Radical by Responsive Fluorescence Nanoprobes
The pro-radical hydrogen peroxide as a stable hydroxyl radical distributor: lessons from pancreatic beta cells
Capture and Stabilization of the Hydroxyl Radical in a Uranyl Peroxide Cluster **
Instantaneous monitoring of hydroxyl radical-mediated protein alterations by green fluorescent protein
Estimation of the atmospheric hydroxyl radical oxidative capacity using multiple hydrofluorocarbons (HFCs)
Secondary organic aerosol formation from hydroxyl radical oxidation and ozonolysis of monoterpenes
The kinetics and mechanism of an aqueous phase isoprene reaction with hydroxyl radical
Catalytically Active Ti‐Based Nanomaterials for Hydroxyl Radical Mediated Clinical X‐Ray Enhancement
Comparison of Hydroxyl Radical, Peroxyl Radical, and Peroxynitrite Scavenging Capacity of Extracts and Active Components from Selected Medicinal Plants
Phenylalanine as a hydroxyl radical-specific probe in pyrite slurries
Accurate protein structure prediction with hydroxyl radical protein footprinting data
Pyrite-induced hydroxyl radical formation and its effect on nucleic acids
Recent Advances in Detection of Hydroxyl Radical by Responsive Fluorescence Nanoprobes
The pro-radical hydrogen peroxide as a stable hydroxyl radical distributor: lessons from pancreatic beta cells
Capture and Stabilization of the Hydroxyl Radical in a Uranyl Peroxide Cluster **
Instantaneous monitoring of hydroxyl radical-mediated protein alterations by green fluorescent protein
Estimation of the atmospheric hydroxyl radical oxidative capacity using multiple hydrofluorocarbons (HFCs)
Secondary organic aerosol formation from hydroxyl radical oxidation and ozonolysis of monoterpenes
The kinetics and mechanism of an aqueous phase isoprene reaction with hydroxyl radical
Catalytically Active Ti‐Based Nanomaterials for Hydroxyl Radical Mediated Clinical X‐Ray Enhancement