Modulating the p53-MDM2 pathway : the therapeutic potential of natural compounds in cancer treatment
Abstract: The p53-MDM2 pathway plays a crucial role regulating tumor suppression and is a focal point of cancer research. This literature review delves into the complex interplay between the tumor suppressor protein p53 and its main regulator MDM2, highlighting their interaction and implications in cancer development and progression. The review compiles and summarizes the existing understanding of the biology and regulation of p53 and MDM2, emphasizing their roles in various cellular processes, including cell cycle regulation, DNA repair, apoptosis, and metabolism. It also discusses the disruption of the p53-MDM2 interaction in different cancer types and its impact on tumor progression and therapeutic resistance. Recent studies have highlighted natural products as promising avenues for targeting the p53-MDM2 pathway. This review categorizes these natural compounds into three groups based on their mechanisms: those that inhibit MDM2 expression or stability, those that prevent p53-MDM2 binding.... https://www.excli.de/excli/article/view/7791
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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Modulating the p53-MDM2 pathway ; volume:23 ; year:2024
EXCLI journal ; 23 (2024)
- Creator
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Ramli, Iman
Cheriet, Thamere
Posadino, Anna Maria
Giordo, Roberta
Fenu, Grazia
Chukwuemeka Nwachukwu, Kingsley
Adebayo Oyewole, Oluwafemi
Oluwaseun Adetunji, Charles
Calina, Daniela
Sharifi-Rad, Javad
Pintus, Gianfranco
- DOI
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10.17179/excli2024-7791
- URN
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urn:nbn:de:101:1-2501170213179.906433437987
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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15.08.2025, 7:27 AM CEST
Data provider
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Ramli, Iman
- Cheriet, Thamere
- Posadino, Anna Maria
- Giordo, Roberta
- Fenu, Grazia
- Chukwuemeka Nwachukwu, Kingsley
- Adebayo Oyewole, Oluwafemi
- Oluwaseun Adetunji, Charles
- Calina, Daniela
- Sharifi-Rad, Javad
- Pintus, Gianfranco
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Evolution of the p53-MDM2 pathway
Targeting MDM2, the antagonist of the tumor suppressor p53
miR-29a sensitizes the response of glioma cells to temozolomide by modulating the P53/MDM2 feedback loop
Explaining oscillations and variability in the p53-Mdm2 system
Stress-specific response of the p53-Mdm2 feedback loop
Tau protein binds to the P53 E3 ubiquitin ligase MDM2
Small-Molecule Inhibitors of p53-MDM2 interactions
The role of the MDM2/p53 axis in anti-tumor immune responses
Inactivation of ribosomal protein S27-like confers radiosensitivity via the Mdm2-p53 and Mdm2–MRN–ATM axes
Targeting the p53-MDM2 and p53-MDMX interaction as a therapeutic strategy for anticancer treatment
Targeting the p53-MDM2 and p53-MDMX interaction as a therapeutic strategy for anticancer treatment
Regulation of p53 and Mdm2 by the Tripartite-Motif-protein 25
Evolution of the p53-MDM2 pathway
Targeting MDM2, the antagonist of the tumor suppressor p53
miR-29a sensitizes the response of glioma cells to temozolomide by modulating the P53/MDM2 feedback loop
Explaining oscillations and variability in the p53-Mdm2 system
Stress-specific response of the p53-Mdm2 feedback loop
Tau protein binds to the P53 E3 ubiquitin ligase MDM2
Small-Molecule Inhibitors of p53-MDM2 interactions
The role of the MDM2/p53 axis in anti-tumor immune responses
Inactivation of ribosomal protein S27-like confers radiosensitivity via the Mdm2-p53 and Mdm2–MRN–ATM axes
Targeting the p53-MDM2 and p53-MDMX interaction as a therapeutic strategy for anticancer treatment
Targeting the p53-MDM2 and p53-MDMX interaction as a therapeutic strategy for anticancer treatment