Dye‐Based Fluorescent Organic Nanoparticles, New Promising Tools for Optogenetics
Abstract: Dye‐based fluorescent organic nanoparticles are a specific class of nanoparticles obtained by nanoprecipitation in water of pure dyes only. While the photophysical and colloidal properties of the nanoparticles strongly depend on the nature of the aggregated dyes, their excellent brightness in the visible and in the near infrared make these nanoparticles a unique and versatile platform for in vivo application. This article examines the promising utilization of these nanoparticles for in vivo optogenetics applications. Their photophysical properties as well as their biocompatibility and their capacity to activate Chrimson opsin in vivo through the fluorescence reabsorption process are demonstrated. Additionally, an illustrative example of employing these nanoparticles in fear reduction in mice through closed‐loop stimulation is presented. Through an optogenetic methodology, the nanoparticles demonstrate an ability to selectively manipulate neurons implicated in the fear response and diminish the latter. Dye‐based fluorescent organic nanoparticles represent a promising and innovative strategy for optogenetic applications, holding substantial potential in the domain of translational neuroscience. This work paves the way for novel therapeutic modalities for neurological and neuropsychiatric disorders.
- Standort
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Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
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Online-Ressource
- Sprache
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Englisch
- Erschienen in
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Dye‐Based Fluorescent Organic Nanoparticles, New Promising Tools for Optogenetics ; day:12 ; month:09 ; year:2024 ; extent:14
Advanced healthcare materials ; (12.09.2024) (gesamt 14)
- Urheber
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Lesas, Jérémy
Bienvenu, Thomas C.M.
Kurek, Eleonore
Verlhac, Jean‐Baptiste
Grivet, Zoé
Têtu, Maude
Girard, Delphine
Lanore, Frédéric
Blanchard‐Desce, Mireille
Herry, Cyril
Daniel, Jonathan
Dejean, Cyril
- DOI
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10.1002/adhm.202402132
- URN
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urn:nbn:de:101:1-2409121414313.613156323686
- Rechteinformation
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
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15.08.2025, 07:38 MESZ
Datenpartner
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Beteiligte
- Lesas, Jérémy
- Bienvenu, Thomas C.M.
- Kurek, Eleonore
- Verlhac, Jean‐Baptiste
- Grivet, Zoé
- Têtu, Maude
- Girard, Delphine
- Lanore, Frédéric
- Blanchard‐Desce, Mireille
- Herry, Cyril
- Daniel, Jonathan
- Dejean, Cyril
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