Tumor‐associated human dendritic cell subsets: Phenotype, functional orientation, and clinical relevance

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Abstract: DCs play a pivotal role in orchestrating innate and adaptive antitumor immunity. Activated DCs can produce large amounts of various proinflammatory cytokines, initiate T‐cell responses, and exhibit direct cytotoxicity against tumor cells. They also efficiently enhance the antitumoral properties of NK cells and T lymphocytes. Based on these capabilities, immunogenic DCs promote tumor elimination and are associated with improved survival of patients. Furthermore, they can essentially contribute to the clinical efficacy of immunotherapeutic strategies for cancer patients. However, depending on their intrinsic properties and the tumor microenvironment, DCs can be rendered dysfunctional and mediate tolerance by producing immunosuppressive cytokines and activating Treg cells. Such tolerogenic DCs can foster tumor progression and are linked to poor prognosis of patients. Here, we focus on recent studies exploring the phenotype, functional orientation, and clinical relevance of tumor‐infiltrating conventional DC1, conventional DC2, plasmacytoid DCs, and monocyte‐derived DCs in translational and clinical settings. In addition, recent findings demonstrating the influence of DCs on the efficacy of immunotherapeutic strategies are summarized.

Location: Deutsche Nationalbibliothek Frankfurt am Main

Extent: Online-Ressource

Language: Englisch

Bibliographic citation: Tumor‐associated human dendritic cell subsets: Phenotype, functional orientation, and clinical relevance ; day:24 ; month:02 ; year:2022 ; extent:9
European journal of immunology ; (24.02.2022) (gesamt 9)

Creator: Plesca, Ioana
Müller, Luise
Böttcher, Jan P.
Medyouf, Hind
Wehner, Rebekka
Schmitz, Marc

DOI: 10.1002/eji.202149487

URN: urn:nbn:de:101:1-2022022514090887784703

Rights: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.

Last update: 15.08.2025, 7:36 AM CEST

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Plesca, Ioana
Müller, Luise
Böttcher, Jan P.
Medyouf, Hind
Wehner, Rebekka
Schmitz, Marc

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