Anticancer and antimicrobial potential of zinc/sodium alginate/polyethylene glycol/d -pinitol nanocomposites against osteosarcoma MG-63 cells

Background: The field of nanomedicine has attracted much interest and is now serving as the impetus for many revolutionary advances in the pharmaceutical industry. Objectives: In the current exploration, we intended to fabricate the zinc/sodium alginate/polyethylene glycol/d-pinitol nanocomposites (ZSP/D-Pin/NCs) and evaluate their antimicrobial and anticancer properties against MG-63 cells. Methods: ZSP/D-Pin/NCs were synthesized and characterized using several techniques and their cytotoxicity was examined against osteosarcoma MG-63 cells and normal 3T3 cells using the MTT assay. The levels of oxidative stress and apoptotic protein were examined using assay kits and fluorescence staining. Results and Conclusion: The findings of several characterization studies revealed the development of agglomerated and crystalline ZSP/D-Pin/NCs. The antimicrobial assay demonstrated that ZSP/D-Pin/NCs substantially inhibited the growth of pathogens. Additionally, the MG-63 cell viability, which was exposed to several doses (1–20 µg) of ZSP/D-Pin/NCs, showed a remarkable decrease at various time periods, i.e., 24, 48, and 72 h without showing toxicity in 3T3 cells. The results of the fluorescence staining assay demonstrated that ZSP/D-Pin/NCs considerably increased apoptosis in the MG-63 cells by triggering oxidative stress. The antioxidants were reduced and upregulated the Bax and caspase expressions in ZSP/D-Pin/NC-treated MG-63 cells.

Object Details

• Location: Deutsche Nationalbibliothek Frankfurt am Main
• Extent: Online-Ressource
• Language: Englisch

References and Relationships

• Bibliographic citation: Anticancer and antimicrobial potential of zinc/sodium alginate/polyethylene glycol/d -pinitol nanocomposites against osteosarcoma MG-63 cells ; volume:12 ; number:1 ; year:2023 ; extent:14 ; Green processing & synthesis ; 12, Heft 1 (2023) (gesamt 14)

Contributors, Places and Time

• Creator: Lakshmanan, Anandaraj ; Govindasamy, Chandramohan ; Sivakumar, Allur Subramaniyan ; Hussein-Al-Ali, Samer Hasan ; Ramesh, Monishsanthosh ; Lakshmanan, Hariprasath

Further information

• DOI: 10.1515/gps-2023-0124
• URN: urn:nbn:de:101:1-2023122913055875827754
• Rights: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
• Last update: 15.08.2025, 7:34 AM CEST